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    NPPB natriuretic peptide B [ Homo sapiens (human) ]

    Gene ID: 4879, updated on 17-Jun-2024

    Summary

    Official Symbol
    NPPBprovided by HGNC
    Official Full Name
    natriuretic peptide Bprovided by HGNC
    Primary source
    HGNC:HGNC:7940
    See related
    Ensembl:ENSG00000120937 MIM:600295; AllianceGenome:HGNC:7940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BNP; Iso-ANP
    Summary
    This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for COVID-19 prognosis.
    Expression
    Restricted expression toward heart (RPKM 1334.9) See more
    Orthologs
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    Genomic context

    See NPPB in Genome Data Viewer
    Location:
    1p36.22
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (11857464..11858945, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (11401560..11403041, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (11917521..11919002, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:11865893-11866878 Neighboring gene chloride voltage-gated channel 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 178 Neighboring gene NPPA antisense RNA 1 Neighboring gene VISTA enhancer hs2123 Neighboring gene natriuretic peptide A Neighboring gene ReSE screen-validated silencer GRCh37_chr1:11919401-11919567 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:11927350-11927499 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:11940245-11940745 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11942675-11943304 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11943305-11943932 Neighboring gene VISTA enhancer hs2125 Neighboring gene SBF1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 179 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:11958895-11959446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 180 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 275 Neighboring gene RNA, U5E small nuclear 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies eight loci associated with blood pressure.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables diuretic hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables hormone receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in blood vessel diameter maintenance NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in body fluid secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of cGMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cGMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cardiac conduction system development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of angiogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of renal sodium excretion TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of urine volume TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein folding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in receptor guanylyl cyclase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of blood pressure NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of vascular permeability TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in vasodilation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    natriuretic peptides B
    Names
    brain natriuretic factor prohormone
    brain type natriuretic peptide
    gamma-brain natriuretic peptide
    natriuretic peptide precursor B
    natriuretic protein
    preproBNP
    proBNP

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002521.3NP_002512.1  natriuretic peptides B preproprotein

      See identical proteins and their annotated locations for NP_002512.1

      Status: REVIEWED

      Source sequence(s)
      AJ708502, AL021155, BC025785, M25296
      Consensus CDS
      CCDS140.1
      UniProtKB/Swiss-Prot
      B0ZBE9, P16860, Q6FGY0, Q9P2Q7
      Related
      ENSP00000365651.3, ENST00000376468.4
      Conserved Domains (1) summary
      pfam00212
      Location:98128
      ANP; Atrial natriuretic peptide

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      11857464..11858945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      11401560..11403041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)