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    NPY neuropeptide Y [ Homo sapiens (human) ]

    Gene ID: 4852, updated on 17-Jun-2024

    Summary

    Official Symbol
    NPYprovided by HGNC
    Official Full Name
    neuropeptide Yprovided by HGNC
    Primary source
    HGNC:HGNC:7955
    See related
    Ensembl:ENSG00000122585 MIM:162640; AllianceGenome:HGNC:7955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PYY4
    Summary
    This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
    Expression
    Biased expression in prostate (RPKM 182.5), brain (RPKM 56.2) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See NPY in Genome Data Viewer
    Location:
    7p15.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (24284190..24291862)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (24422184..24429876)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (24323809..24331481)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986777 Neighboring gene RNA, 5S ribosomal pseudogene 228 Neighboring gene small nucleolar RNA U13 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:24317744-24318943 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:24365511-24365721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:24383660-24384160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:24388531-24389031 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:24435498-24436157 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:24436158-24436818 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:24438272-24438926 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:24440891-24441545 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:24441546-24442200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25741 Neighboring gene NANOG hESC enhancer GRCh37_chr7:24446236-24446807 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:24466273-24466844 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:24466845-24467415 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:24472530-24473088 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:24474463-24475000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25742 Neighboring gene uncharacterized LOC124901601 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:24516814-24517478 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:24517479-24518142 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:24518143-24518806 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:24518807-24519469 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:24562031-24562238 Neighboring gene RNA, U6 small nuclear 1103, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Exploring the genetic basis of chronic periodontitis: a genome-wide association study.
    EBI GWAS Catalog
    Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.
    EBI GWAS Catalog
    Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables calcium channel regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables neuropeptide Y receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in adult feeding behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in central nervous system neuron development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cerebral cortex development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in feeding behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intestinal epithelial cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuron projection development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in neuropeptide signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of appetite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic signaling via neuropeptide IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal dense core vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    pro-neuropeptide Y
    Names
    prepro-neuropeptide Y

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016148.1 RefSeqGene

      Range
      5003..12675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000905.4NP_000896.1  pro-neuropeptide Y preproprotein

      See identical proteins and their annotated locations for NP_000896.1

      Status: REVIEWED

      Source sequence(s)
      AI198311, K01911
      Consensus CDS
      CCDS5387.1
      UniProtKB/Swiss-Prot
      P01303
      UniProtKB/TrEMBL
      A4D158
      Related
      ENSP00000242152.2, ENST00000242152.7
      Conserved Domains (1) summary
      smart00309
      Location:2964
      PAH; Pancreatic hormones / neuropeptide F / peptide YY family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      24284190..24291862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      24422184..24429876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)