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    NGF nerve growth factor [ Homo sapiens (human) ]

    Gene ID: 4803, updated on 17-Jun-2024

    Summary

    Official Symbol
    NGFprovided by HGNC
    Official Full Name
    nerve growth factorprovided by HGNC
    Primary source
    HGNC:HGNC:7808
    See related
    Ensembl:ENSG00000134259 MIM:162030; AllianceGenome:HGNC:7808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NGFB; HSAN5; Beta-NGF
    Summary
    This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in ovary (RPKM 1.3), heart (RPKM 0.5) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NGF in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (115285917..115338249, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (115297082..115349408, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (115828538..115880870, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904359 Neighboring gene tetraspanin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1554 Neighboring gene long intergenic non-protein coding RNA 1765 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:115690783-115691409 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:115721881-115723080 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:115800386-115801585 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:115842590-115843789 Neighboring gene NGF antisense RNA 1 Neighboring gene uncharacterized LOC112268234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:115974228-115974728 Neighboring gene uncharacterized LOC124904375

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
    EBI GWAS Catalog
    Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of NGFB is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
    tat Nerve growth factor synergizes with HIV-1 Tat to induce HIV-1 gene expression in neuronal and glial cell lines PubMed
    tat Expression of HIV-1 Tat in human SK-N-MC cells inhibits the NGF-signaling pathway leading to suppression of MAPK and reduction of Puralpha binding to the Egr-1 promoter PubMed
    tat HIV-1 Tat shows the ability to inhibit the nerve growth factor (NGF)-induced neuronal differentiation of PC12 cells PubMed
    Vpr vpr Treatment of cultured dorsal root ganglion sensory neurons with HIV-1 Vpr downregulates expression of TrKA and pGSK3beta/GSK3beta proteins and pre-treatment with NGF inhibits this Vpr-induced downregulation of TrKA and pGSK3beta/GSK3beta PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC161426, MGC161428

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nerve growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nerve growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nerve development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nerve growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuron projection morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of neuron differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
     
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endosome lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    beta-nerve growth factor
    Names
    nerve growth factor (beta polypeptide)
    nerve growth factor, beta subunit
    pro-nerve growth factor long

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007944.1 RefSeqGene

      Range
      5001..57321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_260

    mRNA and Protein(s)

    1. NM_002506.3NP_002497.2  beta-nerve growth factor precursor

      See identical proteins and their annotated locations for NP_002497.2

      Status: REVIEWED

      Source sequence(s)
      AL512638, BC032517, BE045524, CR541855, X52599
      Consensus CDS
      CCDS882.1
      UniProtKB/Swiss-Prot
      A1A4E5, P01138, Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8
      Related
      ENSP00000358525.2, ENST00000369512.3
      Conserved Domains (1) summary
      pfam00243
      Location:128237
      NGF; Nerve growth factor family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      115285917..115338249 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006710663.4XP_006710726.1  beta-nerve growth factor isoform X2

      See identical proteins and their annotated locations for XP_006710726.1

      UniProtKB/Swiss-Prot
      A1A4E5, P01138, Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8
      Related
      ENSP00000502831.1, ENST00000675637.2
      Conserved Domains (1) summary
      pfam00243
      Location:128237
      NGF; Nerve growth factor family
    2. XM_011541518.3XP_011539820.1  beta-nerve growth factor isoform X1

      UniProtKB/TrEMBL
      A0A346FYQ1
      Conserved Domains (1) summary
      pfam00243
      Location:183291
      NGF; Nerve growth factor family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      115297082..115349408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336790.1XP_054192765.1  beta-nerve growth factor isoform X2

      UniProtKB/Swiss-Prot
      A1A4E5, P01138, Q6FHA0, Q96P60, Q9P2Q8, Q9UKL8
    2. XM_054336789.1XP_054192764.1  beta-nerve growth factor isoform X1

      UniProtKB/TrEMBL
      A0A346FYQ1