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    NFKB2 nuclear factor kappa B subunit 2 [ Homo sapiens (human) ]

    Gene ID: 4791, updated on 8-Jul-2021

    Summary

    Official Symbol
    NFKB2provided by HGNC
    Official Full Name
    nuclear factor kappa B subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:7795
    See related
    Ensembl:ENSG00000077150 MIM:164012
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p52; p100; H2TF1; LYT10; CVID10; LYT-10; NF-kB2; p49/p100
    Summary
    This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
    Expression
    Ubiquitous expression in appendix (RPKM 21.5), bone marrow (RPKM 20.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See NFKB2 in Genome Data Viewer
    Location:
    10q24.32
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (102394110..102402529)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (104153867..104162286)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene paired like homeodomain 3 Neighboring gene golgi brefeldin A resistant guanine nucleotide exchange factor 1 Neighboring gene uncharacterized LOC107984263 Neighboring gene pleckstrin and Sec7 domain containing Neighboring gene F-box and leucine rich repeat protein 15 Neighboring gene CUE domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed
    Envelope transmembrane glycoprotein gp41 env The HIV-1 gp41 cytoplasmic domain-induced NFkappaB activation requires TAK1, RelA, and NEMO proteins PubMed
    env The cytoplasmic domain (residues 704-773) of HIV-1 gp41 induces NFkappaB activation. Deletion of a 12 amino-acid sequence (762CLFSYHRLRDLL) in gp41 leads to a dramatic loss of the NFkappaB activation and tyrosine 766 is particularly important PubMed
    Tat tat HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha PubMed
    tat Treatment of astrocytes with cell-permeable superoxide dismutase (SOD) leads to a decrease in Tat-induced ROS generation and NF-kappaB activation PubMed
    tat HIV-1 Tat activates NFkappaB, causing the induction of CD95 ligand, CD69, iNOS, MCP-1, IL-2, IL-6, IL-8, IL-10, TNF-alpha, VCAM-1, ICAM-1, E-selectin, and MMP-9, as well as monocyte adhesion, cellular activation and angiogenesis PubMed
    tat HIV-1 Tat-mediated transcriptional activation of the HIV-1 LTR promoter requires NFkappaB binding sites in the promoter and involves the activation of NFkappaB by Tat PubMed
    tat In HIV-1 Tat-expressing and HIV-infected astrocytes, endothelin-1 (ET-1) is significantly elevated through NF-kappaB (NF-kappaB)-responsive sites in the ET-1 promoter PubMed
    tat HIV-1 Tat has been shown to bind NFkappaB in vitro in gel shift, GST-pull down and affinity matrix assays PubMed
    tat NFAT-1 negatively regulates HIV-1 Tat-mediated transactivation of the HIV-1 LTR by competing with NFkappaB for its binding to the LTR, thereby blocking the interaction of NFkappaB with Tat PubMed
    tat HIV-1 Tat enhances tumor necrosis factor-induced activation of NFkappaB by downregulating manganese-dependent superoxide dismutase (MnSOD) PubMed
    tat NFkappaB tethers the p160 nuclear receptor co-activator GRIP1 to the HIV-1 LTR promoter, thereby regulating the full activation of this promoter by HIV-1 Tat PubMed
    tat HIV-1 Tat activates NFkappaB through the cellular interferon-inducible, double-stranded RNA dependent protein kinase, PKR PubMed
    tat p56-lck plays a critical role in the activation of NFkappaB by HIV-1 Tat PubMed
    tat Activation of NFkappaB by HIV-1 Tat leads to a reduction in adenylyl cyclase activity and an inhibition of cAMP synthesis PubMed
    tat Activation of NFkappaB by HIV-1 Tat is inhibited by Nitric Oxide PubMed
    Vpr vpr HIV-1 Vpr stimulates non-canonical NFKappaB pathway by inducing the phosphorylation of NFKappaB2 (p100) at serine 866, which leads to process p100 into RelB/p52 and its subsequent nuclear translocation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in NIK/NF-kappaB signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in aging IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in follicular dendritic cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in germinal center formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to cytokine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Bcl3/NF-kappaB2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear factor NF-kappa-B p100 subunit
    Names
    DNA-binding factor KBF2
    NFKB, p52/p100 subunit
    lymphocyte translocation chromosome 10 protein
    nuclear factor Kappa-B, subunit 2
    nuclear factor NF-kappa-B p52 subunit
    nuclear factor of Kappa light chain gene enhancer in B cells 2
    nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
    oncogene Lyt-10
    transcription factor NFKB2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033874.2 RefSeqGene

      Range
      6596..13415
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1347

    mRNA and Protein(s)

    1. NM_001077494.3NP_001070962.1  nuclear factor NF-kappa-B p100 subunit isoform a

      See identical proteins and their annotated locations for NP_001070962.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 5 both encode the same isoform (a).
      Source sequence(s)
      AL121928, S76638
      Consensus CDS
      CCDS41564.1
      UniProtKB/Swiss-Prot
      Q00653
      Related
      ENSP00000358983.3, ENST00000369966.8
      Conserved Domains (7) summary
      cd07934
      Location:38221
      RHD-n_NFkB2; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2)
      cd08798
      Location:774849
      Death_NFkB2_p100; Death domain of the Nuclear Factor-KappaB2 precursor protein p100
      cd00204
      Location:483620
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:228327
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      pfam12796
      Location:531629
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:488547
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:599630
      ANK; ANK repeat [structural motif]
    2. NM_001261403.3NP_001248332.1  nuclear factor NF-kappa-B p100 subunit isoform b

      See identical proteins and their annotated locations for NP_001248332.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2, 3, and 4 encode the same isoform (b).
      Source sequence(s)
      AL121928
      Consensus CDS
      CCDS41565.1
      UniProtKB/Swiss-Prot
      Q00653
      Related
      ENSP00000498308.1, ENST00000652277.1
      Conserved Domains (7) summary
      cd07934
      Location:38221
      RHD-n_NFkB2; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2)
      cd08798
      Location:774849
      Death_NFkB2_p100; Death domain of the Nuclear Factor-KappaB2 precursor protein p100
      cd00204
      Location:483620
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:228327
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      pfam12796
      Location:531629
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:488547
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:599630
      ANK; ANK repeat [structural motif]
    3. NM_001288724.1NP_001275653.1  nuclear factor NF-kappa-B p100 subunit isoform b

      See identical proteins and their annotated locations for NP_001275653.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2, 3, and 4 encode the same isoform (b).
      Source sequence(s)
      AL121928, BC002844, DB091090
      Consensus CDS
      CCDS41565.1
      UniProtKB/Swiss-Prot
      Q00653
      Related
      ENSP00000410256.1, ENST00000428099.6
      Conserved Domains (7) summary
      cd07934
      Location:38221
      RHD-n_NFkB2; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2)
      cd08798
      Location:774849
      Death_NFkB2_p100; Death domain of the Nuclear Factor-KappaB2 precursor protein p100
      cd00204
      Location:483620
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:228327
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      pfam12796
      Location:531629
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:488547
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:599630
      ANK; ANK repeat [structural motif]
    4. NM_001322934.2NP_001309863.1  nuclear factor NF-kappa-B p100 subunit isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) and variant 1 both encode the same isoform (a).
      Source sequence(s)
      AK098415, AL121928, KT935449
      Consensus CDS
      CCDS41564.1
      UniProtKB/Swiss-Prot
      Q00653
      Related
      ENSP00000499294.1, ENST00000661543.1
      Conserved Domains (7) summary
      cd07934
      Location:38221
      RHD-n_NFkB2; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2)
      cd08798
      Location:774849
      Death_NFkB2_p100; Death domain of the Nuclear Factor-KappaB2 precursor protein p100
      cd00204
      Location:483620
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:228327
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      pfam12796
      Location:531629
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:488547
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:599630
      ANK; ANK repeat [structural motif]
    5. NM_001322935.1NP_001309864.1  nuclear factor NF-kappa-B p100 subunit isoform c

      Status: REVIEWED

      Source sequence(s)
      AL121928, BC002844
      UniProtKB/Swiss-Prot
      Q00653
    6. NM_002502.6NP_002493.3  nuclear factor NF-kappa-B p100 subunit isoform b

      See identical proteins and their annotated locations for NP_002493.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 2, 3, and 4 encode the same isoform (b).
      Source sequence(s)
      AL121928
      Consensus CDS
      CCDS41565.1
      UniProtKB/Swiss-Prot
      Q00653
      Related
      ENSP00000189444.6, ENST00000189444.11
      Conserved Domains (7) summary
      cd07934
      Location:38221
      RHD-n_NFkB2; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor kappa B2 (NF-kappa B2)
      cd08798
      Location:774849
      Death_NFkB2_p100; Death domain of the Nuclear Factor-KappaB2 precursor protein p100
      cd00204
      Location:483620
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:228327
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      pfam12796
      Location:531629
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:488547
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:599630
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

      Range
      102394110..102402529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448026.1XP_024303794.1  nuclear factor NF-kappa-B p100 subunit isoform X2

      Conserved Domains (5) summary
      cd08798
      Location:732807
      Death_NFkB2_p100; Death domain of the Nuclear Factor-KappaB2 precursor protein p100
      cd00204
      Location:441578
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:186285
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      sd00045
      Location:557588
      ANK; ANK repeat [structural motif]
      cl08275
      Location:6179
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    2. XM_024448027.1XP_024303795.1  nuclear factor NF-kappa-B p100 subunit isoform X4

      Conserved Domains (3) summary
      cd08798
      Location:419494
      Death_NFkB2_p100; Death domain of the Nuclear Factor-KappaB2 precursor protein p100
      cd00204
      Location:128265
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:244275
      ANK; ANK repeat [structural motif]
    3. XM_017016278.1XP_016871767.1  nuclear factor NF-kappa-B p100 subunit isoform X1

    4. XM_011539830.3XP_011538132.1  nuclear factor NF-kappa-B p100 subunit isoform X3

      See identical proteins and their annotated locations for XP_011538132.1

      Conserved Domains (7) summary
      cd08798
      Location:629704
      Death_NFkB2_p100; Death domain of the Nuclear Factor-KappaB2 precursor protein p100
      cd00204
      Location:338475
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:83182
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      pfam12796
      Location:386484
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:343402
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:454485
      ANK; ANK repeat [structural motif]
      cl08275
      Location:176
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
    5. XM_011539831.2XP_011538133.1  nuclear factor NF-kappa-B p100 subunit isoform X3

      See identical proteins and their annotated locations for XP_011538133.1

      Conserved Domains (7) summary
      cd08798
      Location:629704
      Death_NFkB2_p100; Death domain of the Nuclear Factor-KappaB2 precursor protein p100
      cd00204
      Location:338475
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd01177
      Location:83182
      IPT_NFkappaB; IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to ...
      pfam12796
      Location:386484
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:343402
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:454485
      ANK; ANK repeat [structural motif]
      cl08275
      Location:176
      RHD-n; N-terminal sub-domain of the Rel homology domain (RHD)
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