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    SNCA synuclein alpha [ Canis lupus familiaris (dog) ]

    Gene ID: 478478, updated on 1-Mar-2025
    Official Symbol
    SNCAprovided by VGNC
    Official Full Name
    synuclein alphaprovided by VGNC
    Primary source
    VGNC:VGNC:46596
    See related
    Ensembl:ENSCAFG00845019506 RGD:12175117
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
    NEW
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    See SNCA in Genome Data Viewer
    Location:
    chromosome: 32
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 32 NC_051836.1 (12968680..13133813, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 32 NC_006614.4 (28876711..29040565)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 32 NC_049253.1 (26872693..27039258)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 32 NC_049292.1 (13053952..13218226, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 32 NC_049773.1 (12876233..13041037, complement)

    Chromosome 32 - NC_051836.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119867152 Neighboring gene eukaryotic translation initiation factor 3, subunit L pseudogene Neighboring gene multimerin 1 Neighboring gene 60S ribosomal protein L7a-like Neighboring gene small nucleolar RNA SNORD24

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. Comparison of α-synuclein immunoreactivity in the hippocampus between the adult and aged beagle dogs. Ahn JH, et al. Cell Mol Neurobiol, 2013 Jan. PMID 22972205, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. alpha-syn immunoreactivity apparently increases in the aged beagle hippocampus compared to that in the adult dog.
      Title: Comparison of α-synuclein immunoreactivity in the hippocampus between the adult and aged beagle dogs.
    Submit: New GeneRIF Correction

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cuprous ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of dopamine secretion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synapse organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    alpha-synuclein

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051836.1 Reference ROS_Cfam_1.0

      Range
      12968680..13133813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038444135.1 → XP_038300063.1  alpha-synuclein isoform X4

      UniProtKB/TrEMBL
      A0A8C0JSY7, A0A8C0PHH6, A0A8I3PAH3, A0A8P0NVF7
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    2. XM_038444134.1 → XP_038300062.1  alpha-synuclein isoform X4

      UniProtKB/TrEMBL
      A0A8C0JSY7, A0A8C0PHH6, A0A8I3PAH3, A0A8P0NVF7
      Related
      ENSCAFP00845026956.1, ENSCAFT00845034413.1
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    3. XM_038444132.1 → XP_038300060.1  alpha-synuclein isoform X2

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    4. XM_038444131.1 → XP_038300059.1  alpha-synuclein isoform X1

      UniProtKB/TrEMBL
      A0A8C0PHC9
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    5. XM_038444133.1 → XP_038300061.1  alpha-synuclein isoform X3

      UniProtKB/TrEMBL
      A0A8I3P4W4, A0A8P0PCH3
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    6. XM_038444136.1 → XP_038300064.1  alpha-synuclein isoform X5

      UniProtKB/TrEMBL
      A0A8I3NZ19, A0A8P0THC1
      Related
      ENSCAFP00845027123.1, ENSCAFT00845034627.1
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    RNA

    1. XR_005305728.1 RNA Sequence

    2. XR_005305732.1 RNA Sequence

    3. XR_005305727.1 RNA Sequence

    4. XR_005305730.1 RNA Sequence

    5. XR_005305731.1 RNA Sequence

    6. XR_005305729.1 RNA Sequence

    7. XR_005305725.1 RNA Sequence

    8. XR_005305726.1 RNA Sequence

    9. XR_005305733.1 RNA Sequence

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049292.1 Alternate UMICH_Zoey_3.1

      Range
      13053952..13218226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038518523.1 → XP_038374451.1  alpha-synuclein isoform X4

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    2. XM_038518522.1 → XP_038374450.1  alpha-synuclein isoform X4

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    3. XM_038518520.1 → XP_038374448.1  alpha-synuclein isoform X2

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    4. XM_038518519.1 → XP_038374447.1  alpha-synuclein isoform X1

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    5. XM_038518521.1 → XP_038374449.1  alpha-synuclein isoform X3

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    6. XM_038518524.1 → XP_038374452.1  alpha-synuclein isoform X5

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    RNA

    1. XR_005348829.1 RNA Sequence

    2. XR_005348833.1 RNA Sequence

    3. XR_005348828.1 RNA Sequence

    4. XR_005348831.1 RNA Sequence

    5. XR_005348832.1 RNA Sequence

    6. XR_005348830.1 RNA Sequence

    7. XR_005348826.1 RNA Sequence

    8. XR_005348827.1 RNA Sequence

    9. XR_005348834.1 RNA Sequence

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049773.1 Alternate UNSW_CanFamBas_1.0

      Range
      12876233..13041037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038646469.1 → XP_038502397.1  alpha-synuclein isoform X4

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    2. XM_038646468.1 → XP_038502396.1  alpha-synuclein isoform X4

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    3. XM_038646466.1 → XP_038502394.1  alpha-synuclein isoform X2

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    4. XM_038646465.1 → XP_038502393.1  alpha-synuclein isoform X1

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    5. XM_038646467.1 → XP_038502395.1  alpha-synuclein isoform X3

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    6. XM_038646470.1 → XP_038502398.1  alpha-synuclein isoform X5

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    RNA

    1. XR_005416362.1 RNA Sequence

    2. XR_005416366.1 RNA Sequence

    3. XR_005416361.1 RNA Sequence

    4. XR_005416364.1 RNA Sequence

    5. XR_005416365.1 RNA Sequence

    6. XR_005416363.1 RNA Sequence

    7. XR_005416359.1 RNA Sequence

    8. XR_005416360.1 RNA Sequence

    9. XR_005416367.1 RNA Sequence

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049253.1 Alternate UU_Cfam_GSD_1.0

      Range
      26872693..27039258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038582140.1 → XP_038438068.1  alpha-synuclein isoform X1

      UniProtKB/TrEMBL
      A0A8C0PHC9
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    2. XM_038582144.1 → XP_038438072.1  alpha-synuclein isoform X4

      UniProtKB/TrEMBL
      A0A8C0JSY7, A0A8C0PHH6, A0A8I3PAH3, A0A8P0NVF7
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    3. XM_038582141.1 → XP_038438069.1  alpha-synuclein isoform X2

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    4. XM_038582142.1 → XP_038438070.1  alpha-synuclein isoform X3

      UniProtKB/TrEMBL
      A0A8I3P4W4, A0A8P0PCH3
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    5. XM_038582145.1 → XP_038438073.1  alpha-synuclein isoform X5

      UniProtKB/TrEMBL
      A0A8I3NZ19, A0A8P0THC1
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    6. XM_038582143.1 → XP_038438071.1  alpha-synuclein isoform X4

      UniProtKB/TrEMBL
      A0A8C0JSY7, A0A8C0PHH6, A0A8I3PAH3, A0A8P0NVF7
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    RNA

    1. XR_005382856.1 RNA Sequence

    2. XR_005382860.1 RNA Sequence

    3. XR_005382853.1 RNA Sequence

    4. XR_005382854.1 RNA Sequence

    5. XR_005382861.1 RNA Sequence

    6. XR_005382855.1 RNA Sequence

    7. XR_005382858.1 RNA Sequence

    8. XR_005382859.1 RNA Sequence

    9. XR_005382857.1 RNA Sequence

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006614.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      28876711..29040565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038462084.1 → XP_038318012.1  alpha-synuclein isoform X1

      UniProtKB/TrEMBL
      A0A8C0PHC9
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    2. XM_855821.6 → XP_860914.1  alpha-synuclein isoform X4

      See identical proteins and their annotated locations for XP_860914.1

      UniProtKB/TrEMBL
      A0A8C0JSY7, A0A8C0PHH6, A0A8I3PAH3, A0A8P0NVF7
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    3. XM_022413536.2 → XP_022269244.1  alpha-synuclein isoform X2

      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    4. XM_022413537.2 → XP_022269245.1  alpha-synuclein isoform X3

      UniProtKB/TrEMBL
      A0A8I3P4W4, A0A8P0PCH3
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    5. XM_014110040.3 → XP_013965515.1  alpha-synuclein isoform X5

      UniProtKB/TrEMBL
      A0A8I3NZ19, A0A8P0THC1
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 104
      Synuclein

    6. XM_535656.7 → XP_535656.1  alpha-synuclein isoform X4

      See identical proteins and their annotated locations for XP_535656.1

      UniProtKB/TrEMBL
      A0A8C0JSY7, A0A8C0PHH6, A0A8I3PAH3, A0A8P0NVF7
      Conserved Domains (1) summary
      pfam01387
      Location:1 → 131
      Synuclein

    RNA

    1. XR_002621988.2 RNA Sequence

    2. XR_002621989.2 RNA Sequence

    3. XR_002621983.2 RNA Sequence

    4. XR_002621984.2 RNA Sequence

    5. XR_005317022.1 RNA Sequence

    6. XR_002621986.1 RNA Sequence

    7. XR_002621985.2 RNA Sequence

    8. XR_005317019.1 RNA Sequence

    9. XR_002621987.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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