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    SPP1 secreted phosphoprotein 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 478471, updated on 1-Mar-2025
    Official Symbol
    SPP1provided by VGNC
    Official Full Name
    secreted phosphoprotein 1provided by VGNC
    Primary source
    VGNC:VGNC:46756
    See related
    Ensembl:ENSCAFG00845016131 RGD:12164984
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See SPP1 in Genome Data Viewer
    Location:
    chromosome: 32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 32 NC_051836.1 (11406381..11414630)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 32 NC_006614.4 (30592131..30600371, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 32 NC_049253.1 (28630350..28638599, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 32 NC_049292.1 (11490535..11498773)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 32 NC_049773.1 (11316506..11324744)

    Chromosome 32 - NC_051836.1Genomic Context describing neighboring genes Neighboring gene matrix extracellular phosphoglycoprotein Neighboring gene uncharacterized LOC111093643 Neighboring gene uncharacterized LOC111093685 Neighboring gene polycystin 2, transient receptor potential cation channel Neighboring gene SNW domain-containing protein 1-like Neighboring gene ATP binding cassette subfamily G member 2

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. Osteopontin in seminal plasma and sperm membrane of dogs. Souza FF, et al. Reprod Domest Anim, 2009 Jul. PMID 19754587
    2. Gene expression profile altered by orthodontic tooth movement during healing of surgical alveolar defect. Choi EK, et al. Am J Orthod Dentofacial Orthop, 2017 Jun. PMID 28554456
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional annotations of gene clusters based on differentially expressed genes among groups indicated that the gene expression profile of group DT6 had a stronger similarity to that of group D2 than to group D6. The genes participating in high woven-bone fraction in group DT6 could be identified as TNFSF11, MMP13, SPP1, and DMP1, which were verified by quantitative real-time polymerase chain reactions.
      Title: Gene expression profile altered by orthodontic tooth movement during healing of surgical alveolar defect.
    2. It was concluded that seminal plasma and sperm membranes from dogs contain different isoforms of osteopontin; further studies will be necessary to determine their function in this species.
      Title: Osteopontin in seminal plasma and sperm membrane of dogs.
    Submit: New GeneRIF Correction

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables extracellular matrix binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ossification IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of bone resorption IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    osteopontin
    Names
    secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051836.1 Reference ROS_Cfam_1.0

      Range
      11406381..11414630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038444088.1 → XP_038300016.1  osteopontin isoform X1

      UniProtKB/TrEMBL
      A0A8C0K4H1, A0A8C0PLS6, A0A8I3P1W2
      Related
      ENSCAFP00845022628.1, ENSCAFT00845028748.1
      Conserved Domains (1) summary
      pfam00865
      Location:21 → 299
      Osteopontin

    2. XM_038444089.1 → XP_038300017.1  osteopontin isoform X2

      UniProtKB/TrEMBL
      A0A8C0PHK1, A0A8I3S1Y5
      Related
      ENSCAFP00845022594.1, ENSCAFT00845028705.1
      Conserved Domains (1) summary
      pfam00865
      Location:21 → 272
      Osteopontin

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049292.1 Alternate UMICH_Zoey_3.1

      Range
      11490535..11498773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038518484.1 → XP_038374412.1  osteopontin isoform X1

      Conserved Domains (1) summary
      pfam00865
      Location:21 → 299
      Osteopontin

    2. XM_038518485.1 → XP_038374413.1  osteopontin isoform X2

      Conserved Domains (1) summary
      pfam00865
      Location:21 → 272
      Osteopontin

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049773.1 Alternate UNSW_CanFamBas_1.0

      Range
      11316506..11324744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038646420.1 → XP_038502348.1  osteopontin isoform X1

      Conserved Domains (1) summary
      pfam00865
      Location:21 → 299
      Osteopontin

    2. XM_038646421.1 → XP_038502349.1  osteopontin isoform X2

      Conserved Domains (1) summary
      pfam00865
      Location:21 → 272
      Osteopontin

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049253.1 Alternate UU_Cfam_GSD_1.0

      Range
      28630350..28638599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038582182.1 → XP_038438110.1  osteopontin isoform X1

      UniProtKB/TrEMBL
      A0A8C0K4H1, A0A8C0PLS6, A0A8I3P1W2
      Conserved Domains (1) summary
      pfam00865
      Location:21 → 299
      Osteopontin

    2. XM_038582183.1 → XP_038438111.1  osteopontin isoform X2

      UniProtKB/TrEMBL
      A0A8C0PHK1, A0A8I3S1Y5
      Conserved Domains (1) summary
      pfam00865
      Location:21 → 272
      Osteopontin

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006614.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      30592131..30600371 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003434024.5 → XP_003434072.1  osteopontin isoform X1

      UniProtKB/TrEMBL
      A0A8P0NMW9
      Conserved Domains (1) summary
      pfam00865
      Location:21 → 299
      Osteopontin

    2. XM_003434023.5 → XP_003434071.1  osteopontin isoform X2

      UniProtKB/TrEMBL
      A0A8P0NUY5
      Conserved Domains (1) summary
      pfam00865
      Location:21 → 272
      Osteopontin
    Nucleotide Protein
    Heading Accession and Version

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