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    LRRC18 leucine rich repeat containing 18 [ Homo sapiens (human) ]

    Gene ID: 474354, updated on 5-Mar-2024

    Summary

    Official Symbol
    LRRC18provided by HGNC
    Official Full Name
    leucine rich repeat containing 18provided by HGNC
    Primary source
    HGNC:HGNC:23199
    See related
    Ensembl:ENSG00000165383 MIM:619002; AllianceGenome:HGNC:23199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UNQ933; UNQ9338; VKGE9338
    Summary
    Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 1.7) and lung (RPKM 0.1) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LRRC18 in Genome Data Viewer
    Location:
    10q11.23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (48909480..48939840, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (49758686..49789019, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (50117525..50147885, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene WDFY family member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:49953319-49953863 Neighboring gene ribosomal protein L13a pseudogene 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3343 Neighboring gene uncharacterized LOC105378299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50105363-50106123 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:50156438-50157637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50160179-50160678 Neighboring gene uncharacterized LOC105378298 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:50219965-50220220 Neighboring gene microRNA 4294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3345 Neighboring gene V-set and transmembrane domain containing 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:50264962-50265148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:50316573-50317551

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.
    EBI GWAS Catalog
    Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC34773

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 18

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006939.4NP_001006940.3  leucine-rich repeat-containing protein 18

      See identical proteins and their annotated locations for NP_001006940.3

      Status: VALIDATED

      Source sequence(s)
      AC060234
      Consensus CDS
      CCDS31197.1
      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456
      Conserved Domains (2) summary
      PLN00113
      Location:49188
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:3051
      LRR_RI; leucine-rich repeat [structural motif]
    2. NM_001378102.1NP_001365031.1  leucine-rich repeat-containing protein 18

      Status: VALIDATED

      Source sequence(s)
      AC060234
      Consensus CDS
      CCDS31197.1
      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456
      Related
      ENSP00000363275.3, ENST00000374160.8
      Conserved Domains (2) summary
      PLN00113
      Location:49188
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:3051
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      48909480..48939840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539823.2XP_011538125.1  leucine-rich repeat-containing protein 18 isoform X1

      See identical proteins and their annotated locations for XP_011538125.1

      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456
      Conserved Domains (2) summary
      PLN00113
      Location:49188
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:3051
      LRR_RI; leucine-rich repeat [structural motif]
    2. XM_011539822.2XP_011538124.1  leucine-rich repeat-containing protein 18 isoform X1

      See identical proteins and their annotated locations for XP_011538124.1

      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456
      Conserved Domains (2) summary
      PLN00113
      Location:49188
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:3051
      LRR_RI; leucine-rich repeat [structural motif]
    3. XM_017016276.2XP_016871765.1  leucine-rich repeat-containing protein 18 isoform X1

      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456
      Conserved Domains (2) summary
      PLN00113
      Location:49188
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:3051
      LRR_RI; leucine-rich repeat [structural motif]
    4. XM_011539826.4XP_011538128.1  leucine-rich repeat-containing protein 18 isoform X1

      See identical proteins and their annotated locations for XP_011538128.1

      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456
      Conserved Domains (2) summary
      PLN00113
      Location:49188
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:3051
      LRR_RI; leucine-rich repeat [structural motif]
    5. XM_017016277.3XP_016871766.1  leucine-rich repeat-containing protein 18 isoform X1

      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456
      Conserved Domains (2) summary
      PLN00113
      Location:49188
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:3051
      LRR_RI; leucine-rich repeat [structural motif]
    6. XM_011539828.3XP_011538130.1  leucine-rich repeat-containing protein 18 isoform X1

      See identical proteins and their annotated locations for XP_011538130.1

      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456
      Conserved Domains (2) summary
      PLN00113
      Location:49188
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:3051
      LRR_RI; leucine-rich repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      49758686..49789019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365952.1XP_054221927.1  leucine-rich repeat-containing protein 18 isoform X1

      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456
    2. XM_054365953.1XP_054221928.1  leucine-rich repeat-containing protein 18 isoform X1

      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456
    3. XM_054365951.1XP_054221926.1  leucine-rich repeat-containing protein 18 isoform X1

      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456
    4. XM_054365954.1XP_054221929.1  leucine-rich repeat-containing protein 18 isoform X1

      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456
    5. XM_054365957.1XP_054221932.1  leucine-rich repeat-containing protein 18 isoform X1

      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456
    6. XM_054365956.1XP_054221931.1  leucine-rich repeat-containing protein 18 isoform X1

      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456
    7. XM_054365955.1XP_054221930.1  leucine-rich repeat-containing protein 18 isoform X1

      UniProtKB/Swiss-Prot
      Q6UY02, Q8N456