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    NEDD4 NEDD4 E3 ubiquitin protein ligase [ Homo sapiens (human) ]

    Gene ID: 4734, updated on 9-Jul-2019

    Summary

    Official Symbol
    NEDD4provided by HGNC
    Official Full Name
    NEDD4 E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:HGNC:7727
    See related
    Ensembl:ENSG00000069869 MIM:602278
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RPF1; NEDD4-1
    Summary
    This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]
    Expression
    Ubiquitous expression in placenta (RPKM 6.4), liver (RPKM 5.9) and 23 other tissues See more
    Orthologs

    Genomic context

    See NEDD4 in Genome Data Viewer
    Location:
    15q21.3
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (55826917..55993612, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (56119120..56285835, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene pygopus family PHD finger 1 Neighboring gene protogenin Neighboring gene NEDD4 intron nontranscribed DNase I hypersensitive site-defined enhancer Neighboring gene CNOT6L pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 568, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population.
    NHGRI GWA Catalog
    A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
    NHGRI GWA Catalog
    Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.
    NHGRI GWA Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Expression of NEDD4 upregulates levels of extracellular and intracellular HIV-1 Gag/p24 and Env/gp120 proteins in 293 cells PubMed
    Envelope surface glycoprotein gp160, precursor env Expression of NEDD4 upregulates levels of extracellular and intracellular HIV-1 Gag/p24 and Env/gp120 proteins in 293 cells PubMed
    Nef nef HIV-1 Nef co-localizes with CXCR4, AIP4, NEDD4, CD63/LAMP-1-positive vesicles, and HRS/VPS27-positive ESCRT-0 structures in HeLa cells PubMed
    nef HIV-1 Nef co-localizes with E3 ubiquitin ligases AIP4 and NEDD4. HIV-1 Nef induced degradation of GNAI2 involves AIP4 and NEDD4 through recruitment of AIP4 and NEDD4 by Nef PubMed
    Pr55(Gag) gag Expression of NEDD4 upregulates levels of extracellular and intracellular HIV-1 Gag/p24 and Env/gp120 proteins in 293 cells PubMed
    gag Overexpression of Nedd4-1 rescues the HIV-1 PTAP- mutant budding defects and the ubiquitin ligase activity of Nedd4-1 and the LYPXnL motif of Gag/p6 are required for the Nedd4-1-mediated rescue PubMed
    gag Nedd4 is one possible ubiquitin ligase implicated to interact with the L domain of HIV-1 p6-Gag resulting in monoubiquitination of p6 PubMed
    gag Nedd4-1 facilitation of HIV-1 PTAP(-) release requires basic residues in Gag/NC PubMed
    gag The leucine residues (211LYPL214 motif) within the C2 domain of Nedd4-1 mediate binding to Gag and play a critical role in Nedd4-1-mediated rescue of HIV-1 PTAP(-) PubMed
    gag Ubiquitination of HIV-1 p6-Gag may be important for proper virus release from cells PubMed
    gag The L domain (P(T/S)APP; amino acids 7-11) of HIV-1 p6-Gag interacts with a ubiquitin ligase complex resulting in the monoubiquitination of p6 PubMed
    Vif vif HIV-1 Vif, through amino acids 20-128, binds to the WW domains of hNedd4 and AIP4, two HECT E3 ubiquitin ligases PubMed
    capsid gag Expression of NEDD4 upregulates levels of extracellular and intracellular HIV-1 Gag/p24 and Env/gp120 proteins in 293 cells. NEDD4-induced upregulation of p24 levels is mediated by the C2 domain (residues 20-151) of NEDD4 PubMed
    p6 gag Overexpression of Nedd4-1 rescues the HIV-1 PTAP- mutant budding defects and the ubiquitin ligase activity of Nedd4-1 and the LYPXnL motif of Gag/p6 are required for the Nedd4-1-mediated rescue PubMed
    gag Nedd4 is one possible ubiquitin ligase implicated to interact with the L domain of HIV-1 p6-Gag resulting in monoubiquitination of p6 PubMed
    gag Ubiquitination of HIV-1 p6-Gag may be important for proper virus release from cells PubMed
    gag The L domain (P(T/S)APP; amino acids 7-11) of HIV-1 p6-Gag interacts with a ubiquitin ligase complex resulting in the monoubiquitination of p6 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
      Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Downregulation of ERBB4 signaling, organism-specific biosystem (from REACTOME)
      Downregulation of ERBB4 signaling, organism-specific biosystemWW-domain binding motifs in the C-tail of ERBB4 play an important role in the downregulation of ERBB4 receptor signaling, enabling the interaction of intact ERBB4, ERBB4 m80 and ERBB4 s80 with NEDD4 ...
    • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • ErbB4 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      ErbB4 signaling events, organism-specific biosystem
      ErbB4 signaling events
    • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
      ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Presenilin action in Notch and Wnt signaling, organism-specific biosystem (from Pathway Interaction Database)
      Presenilin action in Notch and Wnt signaling, organism-specific biosystem
      Presenilin action in Notch and Wnt signaling
    • Proteasome Degradation, organism-specific biosystem (from WikiPathways)
      Proteasome Degradation, organism-specific biosystem
      Proteasome Degradation
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem (from Pathway Interaction Database)
      Signaling events mediated by VEGFR1 and VEGFR2, organism-specific biosystem
      Signaling events mediated by VEGFR1 and VEGFR2
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0093, MGC176705

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    beta-2 adrenergic receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphoserine residue binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphothreonine residue binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    proline-rich region binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proline-rich region binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sodium channel inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    development involved in symbiotic interaction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucocorticoid receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosomal transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of sodium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of sodium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of vascular endothelial growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuromuscular junction development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    neuron projection development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of nucleocytoplasmic transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    progesterone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein K63-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein targeting to lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein targeting to lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor internalization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of dendrite morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of macroautophagy TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of potassium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to calcium ion TAS
    Traceable Author Statement
    more info
    PubMed 
    transmission of virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apicolateral plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase NEDD4
    Names
    HECT-type E3 ubiquitin transferase NEDD4
    cell proliferation-inducing gene 53 protein
    neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
    receptor-potentiating factor 1
    NP_001271267.1
    NP_001271268.1
    NP_001271269.1
    NP_001316141.1
    NP_006145.2
    NP_940682.2
    XP_011519926.1
    XP_011519927.1
    XP_011519928.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051072.1 RefSeqGene

      Range
      5001..171830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001284338.1NP_001271267.1  E3 ubiquitin-protein ligase NEDD4 isoform 3

      See identical proteins and their annotated locations for NP_001271267.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains three alternate in-frame exons, compared to variant 2. The encoded isoform (3) is longer than isoform 2.
      Source sequence(s)
      AC009997, AL832063, BC136605, BC144285
      Consensus CDS
      CCDS61644.1
      UniProtKB/Swiss-Prot
      P46934
      Related
      ENSP00000424827.1, ENST00000508342.5
      Conserved Domains (5) summary
      smart00456
      Location:893925
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:9861315
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:9621316
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:769798
      WW; WW domain
      cl14603
      Location:517570
      C2; C2 domain
    2. NM_001284339.1NP_001271268.1  E3 ubiquitin-protein ligase NEDD4 isoform 4

      See identical proteins and their annotated locations for NP_001271268.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains three alternate in-frame exons and uses an alternate in-frame splice site, compared to variant 2. The encoded isoform (4) is longer than isoform 2.
      Source sequence(s)
      AC009997, AL832063, BC136605, BC144285
      Consensus CDS
      CCDS61643.1
      UniProtKB/Swiss-Prot
      P46934
      Related
      ENSP00000422705.1, ENST00000506154.1
      Conserved Domains (5) summary
      smart00456
      Location:877909
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:9701299
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:9461300
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:753782
      WW; WW domain
      cl14603
      Location:517570
      C2; C2 domain
    3. NM_001284340.1NP_001271269.1  E3 ubiquitin-protein ligase NEDD4 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains two alternate in-frame exons, compared to variant 2. The encoded isoform (5) is longer than isoform 2.
      Source sequence(s)
      AC009997, AL832063, AL832359, BC136605, BC144285
      UniProtKB/Swiss-Prot
      P46934
      Conserved Domains (5) summary
      smart00456
      Location:876908
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:9691298
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:9451299
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:752781
      WW; WW domain
      cl14603
      Location:513553
      C2; C2 domain
    4. NM_001329212.2NP_001316141.1  E3 ubiquitin-protein ligase NEDD4 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains multiple exons in the 5' UTR, compared to variant 2. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AC009997, AC039057, AL832063, AL833300, D42055
      UniProtKB/Swiss-Prot
      P46934
      Related
      ENSP00000422455.1, ENST00000508871.5
    5. NM_006154.4NP_006145.2  E3 ubiquitin-protein ligase NEDD4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region, and contains multiple alternate 5' coding exons, compared to variant 2. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (1) is shorter and has a distinct N-terminus, compared to isoform 2.
      Source sequence(s)
      AC009997, AL832063, AL833300, D42055
      Consensus CDS
      CCDS45265.1
      UniProtKB/Swiss-Prot
      P46934
      Related
      ENSP00000410613.3, ENST00000435532.7
      Conserved Domains (5) summary
      cd04033
      Location:20151
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:474506
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:567896
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:543897
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:350379
      WW; WW domain
    6. NM_198400.3NP_940682.2  E3 ubiquitin-protein ligase NEDD4 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform 2.
      Source sequence(s)
      AC009997, AL832063, AL833300, BC035707, BC136605
      Consensus CDS
      CCDS10156.1
      UniProtKB/Swiss-Prot
      P46934
      Related
      ENSP00000345530.2, ENST00000338963.6
      Conserved Domains (4) summary
      smart00456
      Location:821853
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:9141243
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:8901244
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:697726
      WW; WW domain

    RNA

    1. NR_104302.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two internal exons and contains an alternate internal exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC009997, AL832063, AL832359, AL833293, BC136605, BC144285
      Related
      ENST00000503468.5

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      55826917..55993612 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521625.3XP_011519927.1  E3 ubiquitin-protein ligase NEDD4 isoform X2

      See identical proteins and their annotated locations for XP_011519927.1

      Conserved Domains (5) summary
      cd04033
      Location:1100
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:423455
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:516845
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:492846
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:299328
      WW; WW domain
    2. XM_011521626.1XP_011519928.1  E3 ubiquitin-protein ligase NEDD4 isoform X2

      See identical proteins and their annotated locations for XP_011519928.1

      Conserved Domains (5) summary
      cd04033
      Location:1100
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:423455
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:516845
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:492846
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:299328
      WW; WW domain
    3. XM_011521624.3XP_011519926.1  E3 ubiquitin-protein ligase NEDD4 isoform X1

      Conserved Domains (5) summary
      cd04033
      Location:15126
      C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)
      smart00456
      Location:449481
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:542871
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:518872
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:325354
      WW; WW domain
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