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    eIF4E1 eukaryotic translation initiation factor 4E1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45525, updated on 2-Nov-2024

    Summary

    Official Symbol
    eIF4E1provided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 4E1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015218
    Locus tag
    Dmel_CG4035
    See related
    AllianceGenome:FB:FBgn0015218
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0260/09; 0587/11; 0589/11; 0919/12; 1004/13; 2; 7238; CBP; CG4035; CT13384; CT39424; CT39426; D-eIF4E; deIF-4E; dEif-4e; deIF4E; dEif4e; Dmel\CG4035; eIF 4E; eif-4e; eif-4E; eIF-4e; eIF-4E; eIF-4E1; eIF-4E2; eIF-4EII; eif4e; eiF4E; eIF4e; eIF4E; Eif4e; Eif4E; EIF4E; eIF4E-1; eIF4E-1/2; eIF4E-2; eIF4EI; eIF4F; elF4E; IF4E; l(3)07238; l(3)67Af; l(3)S025007; l(3)S026009; l(3)S058711; l(3)S091912
    Summary
    Enables RNA 7-methylguanosine cap binding activity; eukaryotic initiation factor 4G binding activity; and translation initiation factor activity. Involved in RNA metabolic process and translational initiation. Located in cytoplasmic ribonucleoprotein granule; cytosol; and nuclear body. Part of eukaryotic translation initiation factor 4F complex. Is active in muscle cell postsynaptic specialization. Is expressed in several structures, including embryonic/larval midgut primordium; germline cell; gonad; gut section; and somatic cell of testis. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E) and EIF4E1B (eukaryotic translation initiation factor 4E family member 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See eIF4E1 in Genome Data Viewer
    Location:
    67B4-67B4; 3-29 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9399618..9402460, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9392718..9395560, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 67B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA 7-methylguanosine cap binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA cap binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables eukaryotic initiation factor 4G binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation initiation factor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational initiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E1
    Names
    CG4035-PA
    CG4035-PB
    CG4035-PC
    CG4035-PD
    CG4035-PE
    CG4035-PF
    CG4035-PG
    CG4035-PH
    CG4035-PI
    cap binding protein
    eIF4E1-PA
    eIF4E1-PB
    eIF4E1-PC
    eIF4E1-PD
    eIF4E1-PE
    eIF4E1-PF
    eIF4E1-PG
    eIF4E1-PH
    eIF4E1-PI
    eukaryotic initiation factor 4E
    eukaryotic translation initiation factor 4E
    lethal(3)67Af

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9399618..9402460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168333.2NP_729480.1  eukaryotic translation initiation factor 4E1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729480.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P48598
      Related
      FBpp0076216
      Conserved Domains (1) summary
      pfam01652
      Location:71228
      IF4E; Eukaryotic initiation factor 4E
    2. NM_080090.3NP_524829.1  eukaryotic translation initiation factor 4E1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524829.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Related
      FBpp0076215
      Conserved Domains (1) summary
      pfam01652
      Location:82239
      IF4E; Eukaryotic initiation factor 4E
    3. NM_168335.2NP_729482.1  eukaryotic translation initiation factor 4E1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729482.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Related
      FBpp0076217
      Conserved Domains (1) summary
      pfam01652
      Location:82239
      IF4E; Eukaryotic initiation factor 4E
    4. NM_001274698.1NP_001261627.1  eukaryotic translation initiation factor 4E1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261627.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Conserved Domains (1) summary
      pfam01652
      Location:82239
      IF4E; Eukaryotic initiation factor 4E
    5. NM_168338.2NP_729485.1  eukaryotic translation initiation factor 4E1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729485.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Related
      FBpp0076219
      Conserved Domains (1) summary
      pfam01652
      Location:82239
      IF4E; Eukaryotic initiation factor 4E
    6. NM_168334.1NP_729481.1  eukaryotic translation initiation factor 4E1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729481.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Related
      FBpp0076218, FBtr0076490
      Conserved Domains (1) summary
      pfam01652
      Location:82239
      IF4E; Eukaryotic initiation factor 4E
    7. NM_001274697.1NP_001261626.1  eukaryotic translation initiation factor 4E1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261626.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Conserved Domains (1) summary
      pfam01652
      Location:82239
      IF4E; Eukaryotic initiation factor 4E
    8. NM_168336.2NP_729483.1  eukaryotic translation initiation factor 4E1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729483.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Related
      FBpp0076220
      Conserved Domains (1) summary
      pfam01652
      Location:82239
      IF4E; Eukaryotic initiation factor 4E
    9. NM_168337.2NP_729484.1  eukaryotic translation initiation factor 4E1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729484.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1Q6, P48598, Q95SV3, Q9VSX8, Q9VSX9
      UniProtKB/TrEMBL
      M9PBZ9
      Related
      FBpp0076221
      Conserved Domains (1) summary
      pfam01652
      Location:82239
      IF4E; Eukaryotic initiation factor 4E