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    MT-CO2 mitochondrially encoded cytochrome c oxidase II [ Homo sapiens (human) ]

    Gene ID: 4513, updated on 9-Jun-2024

    Summary

    Official Symbol
    MT-CO2provided by HGNC
    Official Full Name
    mitochondrially encoded cytochrome c oxidase IIprovided by HGNC
    Primary source
    HGNC:HGNC:7421
    See related
    MIM:516040; AllianceGenome:HGNC:7421
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    COII; MTCO2; COX2
    Summary
    Contributes to cytochrome-c oxidase activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen and positive regulation of vasoconstriction. Located in mitochondrial inner membrane. Part of respiratory chain complex IV. Biomarker of Huntington's disease and stomach cancer. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See MT-CO2 in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) MT (non-nuclear) NC_012920.1 (7586..8269)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (7586..8269)

    Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene tRNA-Asp Neighboring gene tRNA-Lys Neighboring gene ATP synthase F0 subunit 8 Neighboring gene ATP synthase F0 subunit 6

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed
    capsid gag The interaction of HIV-1 CA with human cellular cytochrome c oxidase II mitochondrial protein (MT-CO2) is identified by yeast two-hybrid screen PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to cytochrome-c oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to cytochrome-c oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables cytochrome-c oxidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ATP synthesis coupled electron transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular respiration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in lactation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial electron transport, cytochrome c to oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitochondrial electron transport, cytochrome c to oxygen NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytochrome c oxidase subunit II
    YP_003024029.1
    • cytochrome c oxidase II

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_012920.1 Reference assembly

      Range
      7586..8269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_003024029.1 cytochrome c oxidase subunit II (mitochondrion) [Homo sapiens]

      See identical proteins and their annotated locations for YP_003024029.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P00403, Q37526
      UniProtKB/TrEMBL
      A0A1B0VYS2, A0A1X7RBF7, A0A343UAQ9, A0A343V3Y6, A0A3Q8UFB0, B2XL43, B3DE06, D7NUN3, F1AZ87, G9LKX8, H9RAX1, H9SYF8, K7WVJ5, L7NVC9, Q09U41, Q15HH9, Q4GQP0, Q7Y626, Q7Y6N0, Q8HNR6, Q8WCW3, Q9B138, Q9B2U8, S4STI1, U5Z487, V9JPM6
      Related
      ENSP00000354876.1
      Conserved Domains (1) summary
      MTH00098
      Location:1227
      COX2; cytochrome c oxidase subunit II; Validated