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    MT-CO1 mitochondrially encoded cytochrome c oxidase I [ Homo sapiens (human) ]

    Gene ID: 4512, updated on 8-Jul-2021

    Summary

    Official Symbol
    MT-CO1provided by HGNC
    Official Full Name
    mitochondrially encoded cytochrome c oxidase Iprovided by HGNC
    Primary source
    HGNC:HGNC:7419
    See related
    MIM:516030
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    COI; MTCO1; COX1
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    Genomic context

    See MT-CO1 in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) MT (non-nuclear) NC_012920.1 (5904..7445)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (5904..7445)

    Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    • Homologs of the COX1 gene: The COX1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, A.thaliana, and frog.
    • Orthologs

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to cytochrome-c oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to cytochrome-c oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in aging IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebellum development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in electron transport coupled proton transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in respiratory electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to copper ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to electrical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cytochrome c oxidase subunit I
    YP_003024028.1
    • cytochrome c oxidase I

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_012920.1 Reference assembly

      Range
      5904..7445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_003024028.1 cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]

      See identical proteins and their annotated locations for YP_003024028.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P00395
      UniProtKB/TrEMBL
      U5YWV7
      Related
      ENSP00000354499.2
      Conserved Domains (1) summary
      MTH00153
      Location:5507
      COX1; cytochrome c oxidase subunit I; Provisional
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