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    MT-ATP8 mitochondrially encoded ATP synthase 8 [ Homo sapiens (human) ]

    Gene ID: 4509, updated on 8-Dec-2022

    Summary

    Official Symbol
    MT-ATP8provided by HGNC
    Official Full Name
    mitochondrially encoded ATP synthase 8provided by HGNC
    Primary source
    HGNC:HGNC:7415
    See related
    MIM:516070; AllianceGenome:HGNC:7415
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATPase8; MTATP8; ATP8
    Summary
    Contributes to proton-transporting ATP synthase activity, rotational mechanism. Involved in mitochondrial ATP synthesis coupled proton transport. Part of mitochondrial proton-transporting ATP synthase complex. Implicated in multiple sclerosis and urinary bladder cancer. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    See MT-ATP8 in Genome Data Viewer
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) MT (non-nuclear) NC_012920.1 (8366..8572)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (8366..8572)

    Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit II Neighboring gene tRNA-Lys Neighboring gene ATP synthase F0 subunit 6 Neighboring gene cytochrome c oxidase subunit III Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    General protein information

    Preferred Names
    ATP synthase F0 subunit 8
    YP_003024030.1
    • ATP synthase 8; ATPase subunit 8

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_012920.1 Reference assembly

      Range
      8366..8572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_003024030.1 ATP synthase F0 subunit 8 (mitochondrion) [Homo sapiens]

      See identical proteins and their annotated locations for YP_003024030.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03928, Q34771
      UniProtKB/TrEMBL
      A0A1X7RCP4, U5YV54
      Related
      ENSP00000355265.1
      Conserved Domains (1) summary
      MTH00102
      Location:167
      ATP8; ATP synthase F0 subunit 8; Validated