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    MT1G metallothionein 1G [ Homo sapiens (human) ]

    Gene ID: 4495, updated on 3-Jun-2024

    Summary

    Official Symbol
    MT1Gprovided by HGNC
    Official Full Name
    metallothionein 1Gprovided by HGNC
    Primary source
    HGNC:HGNC:7399
    See related
    Ensembl:ENSG00000125144 MIM:156353; AllianceGenome:HGNC:7399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MT1; MT1K
    Summary
    Enables zinc ion binding activity. Involved in cellular response to metal ion; cellular response to vascular endothelial growth factor stimulus; and negative regulation of growth. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney (RPKM 963.2), thyroid (RPKM 736.8) and 7 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MT1G in Genome Data Viewer
    Location:
    16q13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (56666730..56668065, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62461707..62463042, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56700642..56701977, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:56691221-56692194 Neighboring gene metallothionein 1F Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:56695770-56696644 Neighboring gene uncharacterized LOC101927536 Neighboring gene metallothionein 1H Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:56708581-56709252 Neighboring gene metallothionein 1I, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC12386

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to cadmium ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to copper ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to copper ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to zinc ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to zinc ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to zinc ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in detoxification of copper ion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monocyte activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in monocyte differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    metallothionein-1G
    Names
    MT-1G
    MT-1K
    MT-IG
    metallothionein-1K
    metallothionein-IG

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301267.2NP_001288196.1  metallothionein-1G isoform 2

      See identical proteins and their annotated locations for NP_001288196.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) is one aa longer than isoform 1.
      Source sequence(s)
      AC026461, BC020757, BM817643
      Consensus CDS
      CCDS76873.1
      UniProtKB/Swiss-Prot
      P13640, P80296
      Related
      ENSP00000369139.4, ENST00000379811.4
      Conserved Domains (1) summary
      pfam00131
      Location:962
      Metallothio; Metallothionein
    2. NM_005950.3NP_005941.1  metallothionein-1G isoform 1

      See identical proteins and their annotated locations for NP_005941.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
      Source sequence(s)
      AC026461, BC020757, BM817643, CD175975
      Consensus CDS
      CCDS10766.1
      UniProtKB/TrEMBL
      Q8TE66
      Related
      ENSP00000391397.2, ENST00000444837.6
      Conserved Domains (1) summary
      pfam00131
      Location:561
      Metallothio; Metallothionein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      56666730..56668065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      62461707..62463042 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)