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    BPY2B basic charge Y-linked 2B [ Homo sapiens (human) ]

    Gene ID: 442867, updated on 17-Jun-2024

    Summary

    Official Symbol
    BPY2Bprovided by HGNC
    Official Full Name
    basic charge Y-linked 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:25449
    See related
    Ensembl:ENSG00000183795 AllianceGenome:HGNC:25449
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VCY2B
    Summary
    This gene is located in the nonrecombining portion of the Y chromosome, and expressed specifically in testis. The encoded protein interacts with ubiquitin protein ligase E3A and may be involved in male germ cell development and male infertility. Three nearly identical copies of this gene exist on chromosome Y; two copies are part of a palindromic region. This record represents the more centromeric copy within the palindrome. [provided by RefSeq, Jul 2008]
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    Genomic context

    See BPY2B in Genome Data Viewer
    Location:
    Yq11.23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (24618004..24639207)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (24223343..24244546, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (26764151..26785354)

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 736 pseudogene 12, Y-linked Neighboring gene testis expressed transcript, Y-linked 4B Neighboring gene tripartite motif containing 60 pseudogene 10, Y-linked Neighboring gene zinc finger protein 736 pseudogene 2, Y-linked

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables HECT domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in single fertilization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    testis-specific basic protein Y 2
    Names
    basic charge, Y-linked 2
    basic protein on Y chromosome 2
    variable charge, Y-linked, 2
    variably charged protein Y 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002760.1NP_001002760.1  testis-specific basic protein Y 2

      See identical proteins and their annotated locations for NP_001002760.1

      Status: REVIEWED

      Source sequence(s)
      AC010153
      Consensus CDS
      CCDS44029.1
      UniProtKB/Swiss-Prot
      O14599
      Related
      ENSP00000371829.1, ENST00000382392.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

      Range
      24618004..24639207
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060948.1 Alternate T2T-CHM13v2.0

      Range
      24223343..24244546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)