U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CDNF cerebral dopamine neurotrophic factor [ Homo sapiens (human) ]

    Gene ID: 441549, updated on 5-Mar-2024

    Summary

    Official Symbol
    CDNFprovided by HGNC
    Official Full Name
    cerebral dopamine neurotrophic factorprovided by HGNC
    Primary source
    HGNC:HGNC:24913
    See related
    Ensembl:ENSG00000185267 MIM:611233; AllianceGenome:HGNC:24913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARMETL1
    Summary
    Predicted to enable growth factor activity. Predicted to be involved in dopaminergic neuron differentiation and neuron projection development. Predicted to be active in endoplasmic reticulum and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 6.6), thyroid (RPKM 2.2) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CDNF in Genome Data Viewer
    Location:
    10p13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (14819245..14838037, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (14833219..14852002, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (14861244..14880036, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 107 member B Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:14716743-14717329 Neighboring gene RNA, 5S ribosomal pseudogene 302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:14779811-14780332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3082 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3083 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:14793464-14794381 Neighboring gene ribosomal protein SA pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3085 Neighboring gene Myb/SANT DNA binding domain containing 7 Neighboring gene heat shock protein family A (Hsp70) member 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2164 Neighboring gene SUV39H2 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in dopaminergic neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cerebral dopamine neurotrophic factor
    Names
    ARMET-like protein 1
    arginine-rich, mutated in early stage tumors-like 1
    conserved dopamine neurotrophic factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029954.3NP_001025125.2  cerebral dopamine neurotrophic factor precursor

      See identical proteins and their annotated locations for NP_001025125.2

      Status: VALIDATED

      Source sequence(s)
      AC069544, AK131035, AV657190, BG213461, BQ025443, CN311321
      Consensus CDS
      CCDS31148.1
      UniProtKB/Swiss-Prot
      A2RUU0, B4DVW3, Q49AH0
      Related
      ENSP00000419395.1, ENST00000465530.2
      Conserved Domains (1) summary
      pfam10208
      Location:36180
      Armet; Degradation arginine-rich protein for mis-folding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      14819245..14838037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519488.3XP_011517790.1  cerebral dopamine neurotrophic factor isoform X1

      Conserved Domains (1) summary
      pfam10208
      Location:36189
      Armet; Degradation arginine-rich protein for mis-folding

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      14833219..14852002 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365950.1XP_054221925.1  cerebral dopamine neurotrophic factor isoform X1