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    AKR1B15 aldo-keto reductase family 1 member B15 [ Homo sapiens (human) ]

    Gene ID: 441282, updated on 26-Oct-2022

    Summary

    Official Symbol
    AKR1B15provided by HGNC
    Official Full Name
    aldo-keto reductase family 1 member B15provided by HGNC
    Primary source
    HGNC:HGNC:37281
    See related
    Ensembl:ENSG00000227471 MIM:616336; AllianceGenome:HGNC:37281
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AKR1B10L; AKR1R1B7; AKR1B10L, AK1R1B7
    Summary
    Enables estradiol 17-beta-dehydrogenase activity. Predicted to be involved in estrogen biosynthetic process. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach (RPKM 12.1), duodenum (RPKM 9.7) and 4 other tissues See more
    Orthologs
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    Genomic context

    See AKR1B15 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (134549110..134579869)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (135857188..135887905)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134233862..134264621)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13664 Neighboring gene uncharacterized LOC105375520 Neighboring gene aldo-keto reductase family 1 member B10 Neighboring gene uncharacterized LOC124901750 Neighboring gene CRISPRi-validated cis-regulatory element chr7.4787 Neighboring gene Sharpr-MPRA regulatory region 13526 Neighboring gene bisphosphoglycerate mutase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NADP-retinol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables alditol:NADP+ 1-oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables allyl-alcohol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables estradiol 17-beta-dehydrogenase activity TAS
    Traceable Author Statement
    more info
     
    enables farnesol dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables testosterone 17-beta-dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in estrogen biosynthetic process TAS
    Traceable Author Statement
    more info
     
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    aldo-keto reductase family 1 member B15
    Names
    estradiol 17-beta-dehydrogenase AKR1B15
    farnesol dehydrogenase
    putative aldo-keto reductase family 1 member B15
    testosterone 17beta-dehydrogenase
    NP_001074007.2
    NP_001354749.1
    NP_001354750.1
    NP_001354751.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080538.3NP_001074007.2  aldo-keto reductase family 1 member B15 isoform a

      See identical proteins and their annotated locations for NP_001074007.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC078847, BX335355
      Consensus CDS
      CCDS47715.2
      UniProtKB/Swiss-Prot
      C9JRZ8
      Related
      ENSP00000389289.1, ENST00000457545.7
      Conserved Domains (2) summary
      COG0656
      Location:56325
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
      COG0667
      Location:57317
      Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
    2. NM_001367820.1NP_001354749.1  aldo-keto reductase family 1 member B15 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC078847
      Consensus CDS
      CCDS47715.2
      Related
      ENSP00000397009.2, ENST00000423958.2
    3. NM_001367821.1NP_001354750.1  aldo-keto reductase family 1 member B15 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC078847
      Consensus CDS
      CCDS94205.1
      UniProtKB/Swiss-Prot
      C9J3V2
      Related
      ENSP00000498877.1, ENST00000652743.1
      Conserved Domains (1) summary
      cd19107
      Location:10316
      AKR_AKR1B1-19; AKR1B family of aldo-keto reductase (AKR)
    4. NM_001367822.1NP_001354751.1  aldo-keto reductase family 1 member B15 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC078847

    RNA

    1. NR_160301.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC078847
      Related
      ENST00000467156.1
    2. NR_160302.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC078847

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      134549110..134579869
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      135857188..135887905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)