U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CTRB2 chymotrypsinogen B2 [ Homo sapiens (human) ]

    Gene ID: 440387, updated on 17-Jun-2024

    Summary

    Official Symbol
    CTRB2provided by HGNC
    Official Full Name
    chymotrypsinogen B2provided by HGNC
    Primary source
    HGNC:HGNC:2522
    See related
    Ensembl:ENSG00000168928 MIM:619620; AllianceGenome:HGNC:2522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This CTRB2 gene is located head-to-head with the related CTRB1 gene. Some human populations have an alternate haplotype which inverts a 16.6 Kb region containing portions of intron 1, exon 1, and the upstream sequence of the CTRB1 and CTRB2 genes. In this inversion haplotype exon 1 and flanking sequence is swapped in CTRB1 and CTRB2. This inversion is associated with differential gene expression and increased risk for chronic pancreatitis. The GRCh38 assembly represents the minor allele for SNP rs8048956 of the CTRB1 gene. SNP rs8048956 is diagnostic for this inversion. [provided by RefSeq, Jan 2021]
    Expression
    Restricted expression toward pancreas (RPKM 32305.1) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CTRB2 in Genome Data Viewer
    Location:
    16q23.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (75204103..75207161, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (81250834..81253906, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (75238001..75241059, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ZFP1 zinc finger protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11123 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7709 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:75231710-75232210 Neighboring gene Sharpr-MPRA regulatory region 2157 Neighboring gene RPS4Y1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11124 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7710 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:75242541-75243096 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:75243097-75243652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11125 Neighboring gene uncharacterized LOC100506281 Neighboring gene chymotrypsinogen B1 Neighboring gene BCAR1 scaffold protein, Cas family member

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ42412

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    chymotrypsinogen B2
    Names
    chymotrypsin B2
    NP_001020371.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025200.4NP_001020371.3  chymotrypsinogen B2 precursor

      See identical proteins and their annotated locations for NP_001020371.3

      Status: VALIDATED

      Source sequence(s)
      AK225933
      Consensus CDS
      CCDS32489.1
      UniProtKB/Swiss-Prot
      A8K707, Q6GPI1
      UniProtKB/TrEMBL
      A0A2R8YG87
      Related
      ENSP00000303963.8, ENST00000303037.13
      Conserved Domains (2) summary
      smart00020
      Location:33256
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:34259
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      75204103..75207161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654723.1 Reference GRCh38.p14 PATCHES

      Range
      34306..40146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      81250834..81253906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)