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    MXRA7 matrix remodeling associated 7 [ Homo sapiens (human) ]

    Gene ID: 439921, updated on 5-Mar-2024

    Summary

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    Official Symbol
    MXRA7provided by HGNC
    Official Full Name
    matrix remodeling associated 7provided by HGNC
    Primary source
    HGNC:HGNC:7541
    See related
    Ensembl:ENSG00000182534 AllianceGenome:HGNC:7541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart (RPKM 51.6), thyroid (RPKM 40.4) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    17q25.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (76672551..76710965, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (77569376..77607924, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (74668633..74707047, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene prothymosin alpha pseudogene 13 Neighboring gene RNA, U6 small nuclear 227, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74666855-74667812 Neighboring gene uncharacterized LOC105274304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74678511-74679057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74680151-74680695 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74682678-74683473 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74693235-74693788 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74693789-74694342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74694343-74694895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74696218-74696722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74696723-74697227 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74697733-74698236 Neighboring gene RNY4 pseudogene 36 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9024 Neighboring gene jumonji domain containing 6, arginine demethylase and lysine hydroxylase Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74722561-74723190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74723821-74724449 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74725107-74725737 Neighboring gene methyltransferase 23, arginine Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74732487-74733112 Neighboring gene serine and arginine rich splicing factor 2 Neighboring gene microRNA 636

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Effect of MXRA7 on the Biological Functions of Acute B Lymphoblastic Leukemia Cell Line REH]. Ma KP, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2023 Feb. PMID 36765476
    2. Altered expression of matrix remodelling associated 7 (MXRA7) in psoriatic epidermis: Evidence for a protective role in the psoriasis imiquimod mouse model. Ning J, et al. Exp Dermatol, 2018 Sep. PMID 29781547
    3. Genetic loci for retinal arteriolar microcirculation. Sim X, et al. PLoS One, 2013. PMID 23776548, Free PMC Article
    4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Zody MC, et al. Nature, 2006 Apr 20. PMID 16625196, Free PMC Article
    5. Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4. Ikeda KN, et al. J Biol Chem, 2019 Jul 26. PMID 31177093, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Critical role of MXRA7 in differentiation blockade in human acute promyelocytic leukemia cells.
      Title: Critical role of MXRA7 in differentiation blockade in human acute promyelocytic leukemia cells.
    2. [Effect of MXRA7 on the Biological Functions of Acute B Lymphoblastic Leukemia Cell Line REH].
      Title: [Effect of MXRA7 on the Biological Functions of Acute B Lymphoblastic Leukemia Cell Line REH].
    3. MXRA7 gene might function as a negative modulator in psoriasis development when propsoriatic factors attack, presumably via expression alteration or redistribution of MXRA7 proteins in keratinocytes.
      Title: Altered expression of matrix remodelling associated 7 (MXRA7) in psoriatic epidermis: Evidence for a protective role in the psoriasis imiquimod mouse model.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic loci for retinal arteriolar microcirculation.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41492, FLJ46603

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    matrix-remodeling-associated protein 7
    Names
    matrix-remodelling associated 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008528.3 → NP_001008528.1  matrix-remodeling-associated protein 7 isoform 1

      See identical proteins and their annotated locations for NP_001008528.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC005837, AW297080, BC053983, CK300836
      Consensus CDS
      CCDS32745.1
      UniProtKB/Swiss-Prot
      P84157, Q0P5W3
      Related
      ENSP00000348050.2, ENST00000355797.7
      Conserved Domains (1) summary
      PHA03247
      Location:52 → 98
      PHA03247; large tegument protein UL36; Provisional

    2. NM_001008529.3 → NP_001008529.1  matrix-remodeling-associated protein 7 isoform 2

      See identical proteins and their annotated locations for NP_001008529.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternate 3' exon structure, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC005837, AK128460, AL046940, AW166143, BC053983
      Consensus CDS
      CCDS32746.1
      UniProtKB/Swiss-Prot
      P84157
      UniProtKB/TrEMBL
      Q6ZR64
      Related
      ENSP00000364176.1, ENST00000375036.6
      Conserved Domains (1) summary
      PHA03247
      Location:52 → 98
      PHA03247; large tegument protein UL36; Provisional

    3. NM_001363769.2 → NP_001350698.1  matrix-remodeling-associated protein 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC005837
      Consensus CDS
      CCDS86640.1
      UniProtKB/TrEMBL
      Q6ZR64
      Related
      ENSP00000465103.1, ENST00000592148.1

    4. NM_001387276.1 → NP_001374205.1  matrix-remodeling-associated protein 7 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) represents the longest transcript and encodes the longest isoform (5).
      Source sequence(s)
      AC005837

    5. NM_001387277.1 → NP_001374206.1  matrix-remodeling-associated protein 7 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC005837

    6. NM_001387278.1 → NP_001374207.1  matrix-remodeling-associated protein 7 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC005837

    7. NM_198530.4 → NP_940932.2  matrix-remodeling-associated protein 7 isoform 3

      See identical proteins and their annotated locations for NP_940932.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC005837, AL046940, BC053983
      Consensus CDS
      CCDS45786.1
      UniProtKB/Swiss-Prot
      P84157
      Related
      ENSP00000391466.1, ENST00000449428.7

    RNA

    1. NR_130926.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005837

    2. NR_130927.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005837

    3. NR_130928.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC005837

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      76672551..76710965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436104.1 → XP_047292060.1  matrix-remodeling-associated protein 7 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      77569376..77607924 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316196.1 → XP_054172171.1  matrix-remodeling-associated protein 7 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P84157.1 GenPept UniProtKB/Swiss-Prot:P84157

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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