Oamb Octopamine receptor in mushroom bodies [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Oambprovided by FlyBase
Official Full Name: Octopamine receptor in mushroom bodiesprovided by FlyBase
Primary source: FLYBASE:FBgn0024944
Locus tag: Dmel_CG3856
See related: AllianceGenome:FB:FBgn0024944
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG15698; CG3856; Dm-OAMB; Dmel\CG3856; Dmoa1; DmOA1A; DmOA1B; DmOAMB; DmOCT1B; DmOctalpha1Rb; GPCR; oamb; OAMB; Oamb a; Oamb b; OAMB-1a; OAMB-AS; OAMB-K3; Oamb1; OAMBII; Oct&agr-1R; OctR; OCTR; OctR1
Summary: Enables octopamine receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of circadian sleep/wake cycle, wakefulness; and positive regulation of ovulation. Predicted to be integral component of membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adult muscle system; central nervous system; reproductive system; terminal tracheal cell; and tracheal system. Human ortholog(s) of this gene implicated in Alzheimer's disease and hypertension. Orthologous to human ADRA1A (adrenoceptor alpha 1A) and ADRA1B (adrenoceptor alpha 1B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 92F6-92F8; 3-69 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (20689018..20714577, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16514740..16540299, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of Drosophila octopamine receptor neuronal expression using MiMIC-converted Gal4 lines.
Title: Characterization of Drosophila octopamine receptor neuronal expression using MiMIC-converted Gal4 lines.
Alpha- and beta-adrenergic octopamine receptors in muscle and heart are required for Drosophila exercise adaptations.
Title: Alpha- and beta-adrenergic octopamine receptors in muscle and heart are required for Drosophila exercise adaptations.
We also show that follicular OA-Oamb signaling induces Mmp2 enzymatic activation but not Mmp2 protein expression, likely via intracellular Ca2+ as the second messenger.
Title: A Follicle Rupture Assay Reveals an Essential Role for Follicular Adrenergic Signaling in Drosophila Ovulation.
Activation of 5-HT1A and OAMB signaling in Insulin-producing cells generates differential effects on Dilp transcription, fly physiology, metabolism and social interactions.
Title: Drosophila insulin-producing cells are differentially modulated by serotonin and octopamine receptors and affect social behavior.
These results indicate that the OAMB receptor is a key molecule mediating the octopamine's signal for appetitive olfactory learning
Title: Appetitive learning requires the alpha1-like octopamine receptor OAMB in the Drosophila mushroom body neurons.
Octopamine plays an important role in courtship conditioning through its OAMB receptor, expressed in a specific neuronal subset of mushroom bodies.
Title: Molecular genetic analysis of sexual rejection: roles of octopamine and its receptor OAMB in Drosophila courtship conditioning.
Results show that Ca2+ signaling initiated by octopamine receptor DmOctalpha1Rb (CG3856) is intimately controlled by kinase and phosphatase activities.
Title: A single amino acid residue controls Ca2+ signaling by an octopamine receptor from Drosophila melanogaster.
Site-directed mutagenesis studies show that the receptor binds various amino acids.
Title: Site-directed mutagenesis studies on the Drosophila octopamine/tyramine receptor.
In neurons, exogenous mushroom body octopamine receptors activate the same signal pathway as endogenous mGluRs, suggesting that diverse neuronal responses mediated by Gq-coupled receptors are due to the properties of different neurons.
Title: Use of the exogenous Drosophila octopamine receptor gene to study Gq-coupled receptor-mediated responses in mammalian neurons.
Our work provides the first evidence that adult abdominal type II visceral innervations co-express Glu and OA and allows us to re-evaluate the previous model of neuronal network controlling insect oviduct contraction.
Title: Oviduct contraction in Drosophila is modulated by a neural network that is both, octopaminergic and glutamatergic.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables octopamine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables octopamine receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway involved in social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of circadian sleep/wake cycle, wakefulness	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of metallopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ovulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: octopamine receptor in mushroom bodies

Names: CG3856-PB; CG3856-PC; CG3856-PD; CG3856-PE; CG3856-PF; CG3856-PG; OAMB; Oamb-PB; Oamb-PC; Oamb-PD; Oamb-PE; Oamb-PF; Oamb-PG; octopamine mushroom body receptor; octopamine receptor; octopamine receptor OAMB; octopamine-activated G-protein-coupled receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

20689018..20714577 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169914.2 → NP_732542.1 octopamine receptor in mushroom bodies, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732542.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61730, Q7JQF1, Q9VDJ6

Related

FBpp0083342

Conserved Domains (2) summary

pfam00001
Location:37 → 181

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:29 → 154

7tm_4; Olfactory receptor
NM_001275845.2 → NP_001262774.1 octopamine receptor in mushroom bodies, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262774.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGK1

Conserved Domains (2) summary

pfam00001
Location:37 → 181

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:29 → 154

7tm_4; Olfactory receptor
NM_169913.2 → NP_732541.1 octopamine receptor in mushroom bodies, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732541.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61730, Q7JQF1, Q9VDJ6

Related

FBpp0303557

Conserved Domains (2) summary

pfam00001
Location:37 → 181

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:29 → 154

7tm_4; Olfactory receptor
NM_001316500.1 → NP_001303429.1 octopamine receptor in mushroom bodies, isoform G [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A126GUW9

Conserved Domains (2) summary

pfam00001
Location:37 → 181

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:29 → 154

7tm_4; Olfactory receptor
NM_079930.4 → NP_524669.2 octopamine receptor in mushroom bodies, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524669.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7JQF1

Related

FBpp0083341

Conserved Domains (2) summary

pfam00001
Location:37 → 181

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:29 → 154

7tm_4; Olfactory receptor
NM_001275846.2 → NP_001262775.1 octopamine receptor in mushroom bodies, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262775.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGF4

Conserved Domains (2) summary

pfam00001
Location:37 → 181

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:29 → 154

7tm_4; Olfactory receptor