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    CG17698 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 4379919, updated on 25-Jan-2024

    Summary

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    Official Symbol
    CG17698provided by FlyBase
    Primary source
    FLYBASE:FBgn0040056
    Locus tag
    Dmel_CG17698
    See related
    AllianceGenome:FB:FBgn0040056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CAMKIIb; CAMKIIB; CG40297; Dmel\CG17698
    Summary
    Predicted to enable calcium ion binding activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to be located in cytoplasm. Orthologous to several human genes including CAMKK1 (calcium/calmodulin dependent protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CG17698 in Genome Data Viewer
    Location:
    80F9-80F9; 3-47 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (23737960..23749058)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (23731060..23742158)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45736 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43941

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Li C, et al. Cell, 2009 May 1. PMID 19395009, Free PMC Article
    2. A Kinome RNAi Screen in Drosophila Identifies Novel Genes Interacting with Lgl, aPKC, and Crb Cell Polarity Genes in Epithelial Tissues. Parsons LM, et al. G3 (Bethesda), 2017 Aug 7. PMID 28611255, Free PMC Article
    3. Genetic and Molecular Analysis of Essential Genes in Centromeric Heterochromatin of the Left Arm of Chromosome 3 in Drosophila melanogaster. Syrzycka M, et al. G3 (Bethesda), 2019 May 7. PMID 30948422, Free PMC Article
    4. Compartmentalized calcium transients trigger dendrite pruning in Drosophila sensory neurons. Kanamori T, et al. Science, 2013 Jun 21. PMID 23722427
    5. The mRNA transportome of the BicD/Egl transport machinery. Vazquez-Pianzola P, et al. RNA Biol, 2017 Jan 2. PMID 27801632, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 23739755-23739845 mobile_element_type = transposon:INE-1{}2324
    • Loc: 23741578-23742357 mobile_element_type = transposon:3S18{}2989
    • Loc: 23742418-23742556 mobile_element_type = transposon:INE-1{}2325
    • Loc: 23743186-23743363 mobile_element_type = transposon:INE-1{}2332
    • Loc: 23745072-23745302 mobile_element_type = transposon:Idefix{}2919

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17698-PA
    CG17698-PD
    CG17698-PE
    CG17698-PF
    NP_001036632.1
    NP_001036633.2
    NP_001036634.1
    NP_001262237.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      23737960..23749058
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043168.2 → NP_001036633.2  uncharacterized protein Dmel_CG17698, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036633.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2C3
      Conserved Domains (2) summary
      smart00220
      Location:283 → 573
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14118
      Location:288 → 574
      STKc_CAMKK; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase

    2. NM_001275308.1 → NP_001262237.1  uncharacterized protein Dmel_CG17698, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262237.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGA6
      Conserved Domains (2) summary
      smart00220
      Location:283 → 486
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:288 → 492
      PKc_like; Protein Kinases, catalytic domain

    3. NM_001043169.2 → NP_001036634.1  uncharacterized protein Dmel_CG17698, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036634.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5LJP6
      Conserved Domains (2) summary
      smart00220
      Location:283 → 555
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14118
      Location:288 → 556
      STKc_CAMKK; Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase

    4. NM_001043167.2 → NP_001036632.1  uncharacterized protein Dmel_CG17698, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036632.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5LJP5
      Conserved Domains (2) summary
      smart00220
      Location:1 → 245
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1 → 246
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V2C3 A4V2C3
    M9PGA6 M9PGA6
    Q5LJP5 Q5LJP5
    Q5LJP6 Q5LJP6

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