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    pan pangolin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43769, updated on 19-Mar-2019

    Summary

    Official Symbol
    panprovided by FlyBase
    Official Full Name
    pangolinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085432
    Locus tag
    Dmel_CG34403
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17964; CG32005; CG34403; d-TCF; Dm Pan; Dmel\CG34403; dTcf; dTCF; DTcf; DTCF; IA5; l(4)102ABb; l(4)13; Lef; LEF; LEF-1; LEF/TCF; LEF/TCF-1; lef1; Lef1; LEF1; LEF1/TCF; Pan; PAN; pan.dTCF; tcf; Tcf; TCF; Tcf-1; Tcf/LEF; TCF/LEF; TCF/LEF1; TCF/Pan
    Old locus tag
    CG17964; CG32005; Dmel_CG17964; Dmel_CG32005

    Genomic context

    See pan in Genome Data Viewer
    Location:
    101F1-102A4; 4-0 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.18 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (69326..114270)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (89952..134896)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene cubitus interruptus Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ribosomal protein S3A Neighboring gene Ankyrin Neighboring gene ncRNA Neighboring gene anne boleyn

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    mobile_element

    • Loc: 100389-100643 mobile_element_type = transposon:INE-1{}4168
    • Loc: 100811-100859 mobile_element_type = transposon:1360{}4751
    • Loc: 111786-112228 mobile_element_type = transposon:INE-1{}4170
    • Loc: 71800-71849 mobile_element_type = transposon:INE-1{}4162
    • Loc: 75444-75627 mobile_element_type = transposon:INE-1{}4164
    • Loc: 76554-81921 mobile_element_type = transposon:I{}1483
    • Loc: 88897-89284 mobile_element_type = transposon:INE-1{}4166

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell elongation involved in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chitin-based larval cuticle pattern formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic pattern specification ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development TAS
    Traceable Author Statement
    more info
    PubMed 
    imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    imaginal disc-derived wing morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mesodermal cell fate determination TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    segment polarity determination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    spiracle morphogenesis, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spiracle morphogenesis, open tracheal system ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    beta-catenin-TCF complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    beta-catenin-TCF complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription factor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    pangolin
    Names
    CG34403-PA
    CG34403-PB
    CG34403-PD
    CG34403-PH
    CG34403-PI
    CG34403-PJ
    CG34403-PQ
    CG34403-PR
    CG34403-PS
    T cell factor
    T-cell factor
    TCF
    lethal 13
    lymphocyte enhancer binding factor 1/T cell factor
    pan-PA
    pan-PB
    pan-PD
    pan-PH
    pan-PI
    pan-PJ
    pan-PQ
    pan-PR
    pan-PS

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      69326..114270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258476.2NP_001245405.1  pangolin, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245405.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9XVM0
      Related
      FBpp0300839, FBtr0308615
      Conserved Domains (2) summary
      cd01388
      Location:272343
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:9158
      CTNNB1_binding; N-terminal CTNNB1 binding
    2. NM_001014685.3NP_001014685.1  pangolin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014685.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91943
      Related
      FBpp0099631, FBtr0100245
      Conserved Domains (2) summary
      cd01388
      Location:272343
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:9158
      CTNNB1_binding; N-terminal CTNNB1 binding
    3. NM_166723.3NP_726527.2  pangolin, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726527.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91943
      Related
      FBpp0306416, FBtr0334301
      Conserved Domains (2) summary
      cd01388
      Location:272343
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:9158
      CTNNB1_binding; N-terminal CTNNB1 binding
    4. NM_079880.6NP_524619.3  pangolin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524619.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91943
      Related
      FBpp0088226, FBtr0089159
      Conserved Domains (2) summary
      cd01388
      Location:272343
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:9158
      CTNNB1_binding; N-terminal CTNNB1 binding
    5. NM_001038709.3NP_001033798.1  pangolin, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033798.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91943
      Related
      FBpp0099632, FBtr0100246
      Conserved Domains (2) summary
      cd01388
      Location:272343
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:9158
      CTNNB1_binding; N-terminal CTNNB1 binding
    6. NM_001258477.2NP_001245406.1  pangolin, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245406.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91943
      Related
      FBpp0301556, FBtr0309803
      Conserved Domains (2) summary
      cd01388
      Location:272343
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:9158
      CTNNB1_binding; N-terminal CTNNB1 binding
    7. NM_166718.3NP_726522.1  pangolin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726522.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91943
      Related
      FBpp0088228, FBtr0089161
      Conserved Domains (2) summary
      cd01388
      Location:272343
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:9158
      CTNNB1_binding; N-terminal CTNNB1 binding
    8. NM_166720.3NP_726524.1  pangolin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726524.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91943
      Related
      FBpp0088229, FBtr0089162
      Conserved Domains (2) summary
      cd01388
      Location:272343
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
      pfam08347
      Location:9158
      CTNNB1_binding; N-terminal CTNNB1 binding
    9. NM_166724.4NP_726528.2  pangolin, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726528.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IMA8
      Related
      FBpp0111569, FBtr0112657
      Conserved Domains (1) summary
      cd01388
      Location:713784
      SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...
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