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    PH4alphaMP prolyl-4-hydroxylase-alpha MP [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43624, updated on 4-Apr-2024

    Summary

    Official Symbol
    PH4alphaMPprovided by FlyBase
    Official Full Name
    prolyl-4-hydroxylase-alpha MPprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026190
    Locus tag
    Dmel_CG9726
    See related
    AllianceGenome:FB:FBgn0026190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    59D7T; CG9726; DM59D7T; Dmel\CG9726; ESTS:59D7T
    Summary
    Predicted to enable procollagen-proline 4-dioxygenase activity. Predicted to be involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

    Location:
    99F6-99F6; 3-100 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30491813..30496153, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26317535..26321875, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Jonah 99Fii Neighboring gene Jonah 99Fi Neighboring gene prolyl-4-hydroxylase-alpha SG2 Neighboring gene prolyl-4-hydroxylase-alpha NE1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    enables procollagen-proline 4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    prolyl-4-hydroxylase-alpha MP
    Names
    CG9726-PA
    PH4alphaMP-PA
    alpha subunit
    prolyl-4-hydroxylase-alpha
    NP_524594.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30491813..30496153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079855.3NP_524594.2  prolyl-4-hydroxylase-alpha MP [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524594.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O97126, Q9VA65
      Related
      FBpp0085051
      Conserved Domains (2) summary
      smart00702
      Location:336509
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:24156
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region