Format

Send to:

Choose Destination
    • Showing Current items.

    MPI mannose phosphate isomerase [ Homo sapiens (human) ]

    Gene ID: 4351, updated on 8-Jul-2021

    Summary

    Official Symbol
    MPIprovided by HGNC
    Official Full Name
    mannose phosphate isomeraseprovided by HGNC
    Primary source
    HGNC:HGNC:7216
    See related
    Ensembl:ENSG00000178802 MIM:154550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PMI; PMI1; CDG1B
    Summary
    Phosphomannose isomerase catalyzes the interconversion of fructose-6-phosphate and mannose-6-phosphate and plays a critical role in maintaining the supply of D-mannose derivatives, which are required for most glycosylation reactions. Mutations in the MPI gene were found in patients with carbohydrate-deficient glycoprotein syndrome, type Ib. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
    Expression
    Ubiquitous expression in duodenum (RPKM 9.9), small intestine (RPKM 9.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MPI in Genome Data Viewer
    Location:
    15q24.1-q24.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74890042..74902219)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75182383..75194560)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene microRNA 6882 Neighboring gene unc-51 like kinase 3 Neighboring gene secretory carrier membrane protein 2 Neighboring gene family with sequence similarity 219 member B Neighboring gene cytochrome c oxidase subunit 5A Neighboring gene ribonuclease P and MRP subunit p25

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of mannose phosphate isomerase (MPI) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    • Homologs of the MPI gene: The MPI gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
    • Orthologs from Annotation Pipeline: 356 organisms have orthologs with human gene MPI
    • Orthologs

    Clone Names

    • FLJ39201

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mannose-6-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mannose-6-phosphate isomerase activity TAS
    Traceable Author Statement
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in GDP-mannose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in GDP-mannose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in GDP-mannose biosynthetic process TAS
    Traceable Author Statement
    more info
     
    involved_in cell wall mannoprotein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mannose to fructose-6-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 

    General protein information

    Preferred Names
    mannose-6-phosphate isomerase
    Names
    phosphohexomutase
    phosphomannose isomerase 1
    NP_001276084.1
    NP_001276085.1
    NP_001276086.1
    NP_001317301.1
    NP_002426.1
    XP_016877697.1
    XP_016877698.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008921.1 RefSeqGene

      Range
      4943..14389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001289155.2NP_001276084.1  mannose-6-phosphate isomerase isoform 2

      See identical proteins and their annotated locations for NP_001276084.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compare to isoform 1.
      Source sequence(s)
      AC125435, AF504648, AW445009, AW813817, BX648475, CD706167
      Consensus CDS
      CCDS73756.1
      UniProtKB/TrEMBL
      H3BPP3, Q8NHZ6
      Related
      ENSP00000455405.1, ENST00000566377.5
      Conserved Domains (1) summary
      pfam01238
      Location:6281
      PMI_typeI; Phosphomannose isomerase type I
    2. NM_001289156.2NP_001276085.1  mannose-6-phosphate isomerase isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks part of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC125435, AK301370, AW445009, AW813817, BC046357, BX648475
      Consensus CDS
      CCDS73758.1
      UniProtKB/Swiss-Prot
      P34949
      UniProtKB/TrEMBL
      B4DW50, F5GX71
      Related
      ENSP00000440447.1, ENST00000535694.5
      Conserved Domains (1) summary
      pfam01238
      Location:1332
      PMI_typeI; Phosphomannose isomerase type I
    3. NM_001289157.2NP_001276086.1  mannose-6-phosphate isomerase isoform 4

      See identical proteins and their annotated locations for NP_001276086.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (4) is shorter, compared to isoform 1.
      Source sequence(s)
      AC125435, AW445009, AW813817, BC017351, BX648475, CD706167
      Consensus CDS
      CCDS73757.1
      UniProtKB/Swiss-Prot
      P34949
      Related
      ENSP00000318192.6, ENST00000323744.10
      Conserved Domains (1) summary
      pfam01238
      Location:6321
      PMI_typeI; Phosphomannose isomerase type I
    4. NM_001330372.2NP_001317301.1  mannose-6-phosphate isomerase isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site, resulting in a distinct 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (5) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC125435, AW445009
      Consensus CDS
      CCDS81908.1
      UniProtKB/TrEMBL
      H3BPB8
      Related
      ENSP00000455241.1, ENST00000563786.5
      Conserved Domains (2) summary
      COG1482
      Location:23399
      ManA; Mannose-6-phosphate isomerase, class I [Carbohydrate transport and metabolism]
      pfam01238
      Location:1362
      PMI_typeI; Phosphomannose isomerase type I
    5. NM_002435.3NP_002426.1  mannose-6-phosphate isomerase isoform 1

      See identical proteins and their annotated locations for NP_002426.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC125435, AW445009, AW813817, BC046357, BX648475, CD706167
      Consensus CDS
      CCDS10272.1
      UniProtKB/Swiss-Prot
      P34949
      Related
      ENSP00000318318.6, ENST00000352410.9
      Conserved Domains (1) summary
      pfam01238
      Location:6382
      PMI_typeI; Phosphomannose isomerase type I

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      74890042..74902219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022208.1XP_016877697.1  mannose-6-phosphate isomerase isoform X1

      UniProtKB/TrEMBL
      Q8NHZ6
      Related
      ENSP00000455161.1, ENST00000569931.5
      Conserved Domains (1) summary
      pfam01238
      Location:1261
      PMI_typeI; Phosphomannose isomerase type I
    2. XM_017022209.2XP_016877698.1  mannose-6-phosphate isomerase isoform X2

    Support Center