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    CD200 CD200 molecule [ Homo sapiens (human) ]

    Gene ID: 4345, updated on 27-Nov-2024

    Summary

    Official Symbol
    CD200provided by HGNC
    Official Full Name
    CD200 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:7203
    See related
    Ensembl:ENSG00000091972 MIM:155970; AllianceGenome:HGNC:7203
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRC; MOX1; MOX2; OX-2
    Summary
    This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
    Expression
    Broad expression in brain (RPKM 5.4), placenta (RPKM 3.5) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CD200 in Genome Data Viewer
    Location:
    3q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (112332573..112362812)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (115053635..115083861)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (112051420..112081659)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member C1 Neighboring gene uncharacterized LOC124909407 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:111904045-111904638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:111904639-111905231 Neighboring gene INAVA pseudogene 1 Neighboring gene ubiquitination factor E4A (UFD2 homolog, yeast) pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14603 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112020972-112021844 Neighboring gene uncharacterized LOC105374042 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:112051670-112052627 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:112052628-112053584 Neighboring gene NANOG hESC enhancer GRCh37_chr3:112054081-112054840 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:112073606-112074235 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20238 Neighboring gene uncharacterized LOC105374041 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:112109833-112110448 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20239 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112118629-112119141 Neighboring gene uncharacterized LOC124909408 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:112119654-112120166 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112119142-112119653 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:112125128-112125650 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:112132473-112132973 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:112135621-112136474 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:112136475-112137328 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:112137329-112138182 Neighboring gene 3q13.2-q13.31 proximal HERV-H recombination region Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:112141599-112142451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20240 Neighboring gene NANOG hESC enhancer GRCh37_chr3:112184939-112185454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:112192511-112193011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20243 Neighboring gene B and T lymphocyte associated

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glycosylated region protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding involved in heterotypic cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heterotypic cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heterotypic cell-cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in heterotypic cell-cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of T cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of leukocyte activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of macrophage activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of macrophage migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of matrix metallopeptidase secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of neuroinflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of neuroinflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of CREB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of arginase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of protein-glutamine gamma-glutamyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of transforming growth factor beta production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of neuroinflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell surface TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in neuron projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    OX-2 membrane glycoprotein
    Names
    CD200 antigen
    antigen identified by monoclonal antibody MRC OX-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004196.4NP_001004196.2  OX-2 membrane glycoprotein isoform b

      See identical proteins and their annotated locations for NP_001004196.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon in the 5' coding region, compared to variant 1, that results in an isoform (b) with a longer N-terminus, compared to isoform a.
      Source sequence(s)
      AC112487, AK297194, AL832529
      Consensus CDS
      CCDS33818.1
      UniProtKB/TrEMBL
      A0AAQ5BHQ1
      Related
      ENSP00000420298.1, ENST00000473539.5
      Conserved Domains (2) summary
      cd05846
      Location:69165
      Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
      cl11960
      Location:181253
      Ig; Immunoglobulin domain
    2. NM_001318826.2NP_001305755.1  OX-2 membrane glycoprotein isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon resulting in a distinct 5' UTR and translation initiation at an alternate start codon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct N-terminus, compared to isoform a. Both variants 3 and 5 encode the same protein (isoform c).
      Source sequence(s)
      AC112487, AK312563, AL832529, DA773259
      Conserved Domains (1) summary
      cl11960
      Location:43112
      Ig; Immunoglobulin domain
    3. NM_001318828.2NP_001305757.1  OX-2 membrane glycoprotein isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC112487, AK293399, AL832529, BC022522, DA773259
      Consensus CDS
      CCDS82819.1
      UniProtKB/TrEMBL
      B4DDZ6, F8W7G1
      Related
      ENSP00000373179.3, ENST00000383681.7
      Conserved Domains (2) summary
      cd00096
      Location:913
      Ig; Ig strand C" [structural motif]
      cl11960
      Location:165
      Ig; Immunoglobulin domain
    4. NM_001318830.2NP_001305759.1  OX-2 membrane glycoprotein isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in a shorter isoform (c) with a distinct N-terminus, compared to isoform a. Both variants 3 and 5 encode the same protein (isoform c).
      Source sequence(s)
      AK129797, AL832529, DA773259
      Conserved Domains (1) summary
      cl11960
      Location:43112
      Ig; Immunoglobulin domain
    5. NM_001365851.2NP_001352780.1  OX-2 membrane glycoprotein isoform e precursor

      Status: REVIEWED

      Source sequence(s)
      AC112487
      UniProtKB/Swiss-Prot
      B3KQI1, B4DLW9, D3DN65, P41217, Q6J2Q6, Q6PIQ4, Q8TB85, Q9H3J3
      UniProtKB/TrEMBL
      A0AAQ5BHQ1
      Related
      ENSP00000519490.1, ENST00000714207.1
      Conserved Domains (2) summary
      cd05846
      Location:44138
      Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar domains
      cl11960
      Location:159228
      Ig; Immunoglobulin domain
    6. NM_001365852.1NP_001352781.1  OX-2 membrane glycoprotein isoform f precursor

      Status: REVIEWED

      Source sequence(s)
      AC112487
      UniProtKB/TrEMBL
      A0AAQ5BHQ1, U3KQQ2
      Related
      ENSP00000519478.1, ENST00000714188.1
      Conserved Domains (3) summary
      cd00096
      Location:160166
      Ig; Ig strand C [structural motif]
      cd05846
      Location:25132
      IgV_1_MRC-OX-2_like; First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains
      cl11960
      Location:152223
      Ig; Immunoglobulin domain
    7. NM_001365853.1NP_001352782.1  OX-2 membrane glycoprotein isoform f precursor

      Status: REVIEWED

      Source sequence(s)
      AC112487
      UniProtKB/TrEMBL
      A0AAQ5BHQ1, U3KQQ2
      Related
      ENSP00000476114.2, ENST00000607597.2
      Conserved Domains (3) summary
      cd00096
      Location:160166
      Ig; Ig strand C [structural motif]
      cd05846
      Location:25132
      IgV_1_MRC-OX-2_like; First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains
      cl11960
      Location:152223
      Ig; Immunoglobulin domain
    8. NM_001365854.1NP_001352783.1  OX-2 membrane glycoprotein isoform f precursor

      Status: REVIEWED

      Source sequence(s)
      AC112487
      UniProtKB/TrEMBL
      A0AAQ5BHQ1, U3KQQ2
      Related
      ENSP00000519488.1, ENST00000714205.1
      Conserved Domains (3) summary
      cd00096
      Location:160166
      Ig; Ig strand C [structural motif]
      cd05846
      Location:25132
      IgV_1_MRC-OX-2_like; First immunoglobulin (Ig) variable (V) domain of rat MRC OX-2 antigen, and similar domains
      cl11960
      Location:152223
      Ig; Immunoglobulin domain
    9. NM_001365855.1NP_001352784.1  OX-2 membrane glycoprotein isoform c

      Status: REVIEWED

      Source sequence(s)
      AC112487
      Conserved Domains (1) summary
      cl11960
      Location:43112
      Ig; Immunoglobulin domain
    10. NM_005944.7NP_005935.4  OX-2 membrane glycoprotein isoform a precursor

      See identical proteins and their annotated locations for NP_005935.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AL832529, BC022522, DA544134
      Consensus CDS
      CCDS2965.1
      UniProtKB/TrEMBL
      A0AAQ5BHQ1
      Related
      ENSP00000312766.8, ENST00000315711.12
      Conserved Domains (2) summary
      cd05846
      Location:44140
      Ig1_MRC-OX-2_like; First immunoglobulin (Ig) domain of rat MRC OX-2 antigen (also known as CD200) and similar proteins
      cl11960
      Location:156228
      Ig; Immunoglobulin domain

    RNA

    1. NR_158642.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112487
      Related
      ENST00000498096.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      112332573..112362812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      115053635..115083861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001004197.1: Suppressed sequence

      Description
      NM_001004197.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.