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    Lrrc8b leucine rich repeat containing 8 family, member B [ Mus musculus (house mouse) ]

    Gene ID: 433926, updated on 16-Oct-2021

    Summary

    Official Symbol
    Lrrc8bprovided by MGI
    Official Full Name
    leucine rich repeat containing 8 family, member Bprovided by MGI
    Primary source
    MGI:MGI:2141353
    See related
    Ensembl:ENSMUSG00000070639
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    R75581; Ta-lrrp; mKIAA0231; 2210408K08Rik
    Expression
    Biased expression in testis adult (RPKM 142.7), adrenal adult (RPKM 13.7) and 5 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lrrc8b in Genome Data Viewer
    Location:
    5; 5 E5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (105563072..105637945)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (105415206..105490079)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (105844794..105915208)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26519 Neighboring gene RIKEN cDNA 4930542N06 gene Neighboring gene predicted gene, 32051 Neighboring gene predicted gene, 42141 Neighboring gene predicted gene, 42144

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA0231

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to volume-sensitive anion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in anion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ion channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    volume-regulated anion channel subunit LRRC8B
    Names
    T-cell activation leucine repeat-rich protein
    leucine-rich repeat-containing protein 8B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033550.3NP_001028722.1  volume-regulated anion channel subunit LRRC8B

      See identical proteins and their annotated locations for NP_001028722.1

      Status: VALIDATED

      Source sequence(s)
      AC138265, AK083378
      Consensus CDS
      CCDS39193.1
      UniProtKB/Swiss-Prot
      Q5DU41
      Related
      ENSMUSP00000108327.2, ENSMUST00000112707.3
      Conserved Domains (4) summary
      PLN00113
      Location:428692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578794
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1334
      Pannexin_like; Pannexin-like TM region of LRRC8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      105563072..105637945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254652.1XP_030110512.1  volume-regulated anion channel subunit LRRC8B isoform X1

      Conserved Domains (4) summary
      PLN00113
      Location:428692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578794
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1334
      Pannexin_like; Pannexin-like TM region of LRRC8
    2. XM_030254653.1XP_030110513.1  volume-regulated anion channel subunit LRRC8B isoform X1

      Conserved Domains (4) summary
      PLN00113
      Location:428692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578794
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1334
      Pannexin_like; Pannexin-like TM region of LRRC8
    3. XM_030254651.2XP_030110511.1  volume-regulated anion channel subunit LRRC8B isoform X1

      Conserved Domains (4) summary
      PLN00113
      Location:428692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578794
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1334
      Pannexin_like; Pannexin-like TM region of LRRC8
    4. XM_011249508.3XP_011247810.1  volume-regulated anion channel subunit LRRC8B isoform X1

      See identical proteins and their annotated locations for XP_011247810.1

      UniProtKB/Swiss-Prot
      Q5DU41
      Conserved Domains (4) summary
      PLN00113
      Location:428692
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      COG4886
      Location:578794
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:465488
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12534
      Location:1334
      Pannexin_like; Pannexin-like TM region of LRRC8
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