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    Pusl1 pseudouridylate synthase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 433813, updated on 23-May-2018

    Summary

    Official Symbol
    Pusl1provided by MGI
    Official Full Name
    pseudouridylate synthase-like 1provided by MGI
    Primary source
    MGI:MGI:3047787
    See related
    Ensembl:ENSMUSG00000051557 Vega:OTTMUSG00000010889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D18346; AI853843; 2810021I11Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 20.1), adrenal adult (RPKM 18.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pusl1 in Genome Data Viewer
    Location:
    4 E2; 4 87.66 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (155888857..155891851, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (155262966..155265871, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste receptor, type 1, member 3 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene integrator complex subunit 11 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 Neighboring gene sodium channel, nonvoltage-gated 1, delta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    RNA modification IEA
    Inferred from Electronic Annotation
    more info
     
    pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    tRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tRNA pseudouridine synthase-like 1
    Names
    tRNA pseudouridylate synthase-like 1
    tRNA-uridine isomerase-like 1
    NP_001028662.1
    XP_006539075.1
    XP_017175791.1
    XP_017175792.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033490.1NP_001028662.1  tRNA pseudouridine synthase-like 1

      See identical proteins and their annotated locations for NP_001028662.1

      Status: VALIDATED

      Source sequence(s)
      AL670236
      Consensus CDS
      CCDS51404.1
      UniProtKB/Swiss-Prot
      A2ADA5
      Related
      ENSMUSP00000095344.4, OTTMUSP00000011686, ENSMUST00000097737.4, OTTMUST00000025517
      Conserved Domains (2) summary
      cd02570
      Location:18284
      PseudoU_synth_EcTruA; Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA
      PRK00021
      Location:13284
      truA; tRNA pseudouridine synthase A; Validated

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      155888857..155891851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320303.1XP_017175792.1  tRNA pseudouridine synthase-like 1 isoform X3

      Conserved Domains (1) summary
      cl00130
      Location:2123
      PseudoU_synth; Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi)
    2. XM_006539012.1XP_006539075.1  tRNA pseudouridine synthase-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006539075.1

      UniProtKB/Swiss-Prot
      A2ADA5
      Conserved Domains (2) summary
      cd02570
      Location:10273
      PseudoU_synth_EcTruA; Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA
      TIGR00071
      Location:3268
      hisT_truA; tRNA pseudouridine(38-40) synthase
    3. XM_017320302.1XP_017175791.1  tRNA pseudouridine synthase-like 1 isoform X2

    RNA

    1. XR_390764.2 RNA Sequence

    2. XR_001784162.1 RNA Sequence

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