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    Hdac1 histone deacetylase 1 [ Mus musculus (house mouse) ]

    Gene ID: 433759, updated on 11-Nov-2018

    Summary

    Official Symbol
    Hdac1provided by MGI
    Official Full Name
    histone deacetylase 1provided by MGI
    Primary source
    MGI:MGI:108086
    See related
    Ensembl:ENSMUSG00000028800 Vega:OTTMUSG00000009661
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HD1; RPD3; MommeD5; Hdac1-ps
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 54.8), placenta adult (RPKM 51.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Hdac1 in Genome Data Viewer
    Location:
    4 D2.2; 4 63.26 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (129516104..129542646, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (129193348..129219890, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 229, member A Neighboring gene MARCKS-like 1 Neighboring gene lymphocyte protein tyrosine kinase Neighboring gene microRNA 8119 Neighboring gene family with sequence similarity 167, member B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102534, MGC118085

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    E-box binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Krueppel-associated box domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
    Inferred from Electronic Annotation
    more info
     
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II repressing transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase II repressing transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    activating transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    repressing transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin organization TAS
    Traceable Author Statement
    more info
    PubMed 
    circadian regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryonic digit morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endoderm development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermal cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    eyelid development in camera-type eye IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    fungiform papilla formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hair follicle placode formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hippocampus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    histone H3 deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H3 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H3 deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone H4 deacetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone H4 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H4 deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    methylation-dependent chromatin silencing ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation by host of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of I-kappaB kinase/NF-kappaB signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidyl-lysine acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    odontogenesis of dentin-containing tooth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chemokine (C-X-C motif) ligand 2 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-1 production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of oligodendrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of oligodendrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tyrosine phosphorylation of STAT protein ISO
    Inferred from Sequence Orthology
    more info
     
    protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    response to amphetamine ISO
    Inferred from Sequence Orthology
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    NuRD complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NuRD complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NuRD complex ISO
    Inferred from Sequence Orthology
    more info
     
    Sin3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    histone deacetylase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone deacetylase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcriptional repressor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    histone deacetylase 1
    NP_032254.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008228.2NP_032254.1  histone deacetylase 1

      See identical proteins and their annotated locations for NP_032254.1

      Status: PROVISIONAL

      Source sequence(s)
      AL606921
      Consensus CDS
      CCDS18696.1
      UniProtKB/Swiss-Prot
      O09106
      UniProtKB/TrEMBL
      Q58E49
      Related
      ENSMUSP00000099657.4, OTTMUSP00000010171, ENSMUST00000102597.4, OTTMUST00000022290
      Conserved Domains (1) summary
      cd10010
      Location:4374
      HDAC1; Histone deacetylase 1 (HDAC1)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      129516104..129542646 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187023.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      1118062..1142205 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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