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    Otulin OTU deubiquitinase with linear linkage specificity [ Mus musculus (house mouse) ]

    Gene ID: 432940, updated on 31-Jan-2019

    Summary

    Official Symbol
    Otulinprovided by MGI
    Official Full Name
    OTU deubiquitinase with linear linkage specificityprovided by MGI
    Primary source
    MGI:MGI:3577015
    See related
    Ensembl:ENSMUSG00000046034
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C79097; m3Sapc; Fam105b; m7-1Sapc
    Expression
    Ubiquitous expression in spleen adult (RPKM 20.9), ovary adult (RPKM 16.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Otulin in Genome Data Viewer
    Location:
    15; 15 B1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (27605917..27630980, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (27535674..27560448, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene progressive ankylosis Neighboring gene predicted gene, 29901 Neighboring gene microRNA 7117 Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene OTU deubiquitinase with linear linkage specificity like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Chemically induced (ENU) (2)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    thiol-dependent ubiquitin-specific protease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thiol-dependent ubiquitin-specific protease activity ISO
    Inferred from Sequence Orthology
    more info
     
    thiol-dependent ubiquitinyl hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    protein linear deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein linear deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein linear deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of tumor necrosis factor-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of tumor necrosis factor-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of tumor necrosis factor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with LUBAC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with LUBAC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ubiquitin thioesterase otulin
    Names
    OTU domain-containing deubiquitinase with linear linkage specificity
    deubiquitinating enzyme otulin
    family with sequence similarity 105, member B
    gumby
    protein FAM105B
    ubiquitin thioesterase Gumby
    NP_001013814.2
    XP_006520167.1
    XP_006520168.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013792.2NP_001013814.2  ubiquitin thioesterase otulin

      See identical proteins and their annotated locations for NP_001013814.2

      Status: VALIDATED

      Source sequence(s)
      AK150371, BC087945
      Consensus CDS
      CCDS49586.1
      UniProtKB/Swiss-Prot
      Q3UCV8
      Related
      ENSMUSP00000057893.7, ENSMUST00000059662.7
      Conserved Domains (1) summary
      pfam16218
      Location:81344
      Peptidase_C101; Peptidase family C101

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      27605917..27630980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520105.1XP_006520168.1  ubiquitin thioesterase otulin isoform X2

      Conserved Domains (1) summary
      pfam16218
      Location:1259
      Peptidase_C101; Peptidase family C101
    2. XM_006520104.1XP_006520167.1  ubiquitin thioesterase otulin isoform X1

      Conserved Domains (1) summary
      pfam16218
      Location:60323
      Peptidase_C101; Peptidase family C101
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