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    Akap7 A kinase (PRKA) anchor protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 432442, updated on 5-Sep-2021

    Summary

    Official Symbol
    Akap7provided by MGI
    Official Full Name
    A kinase (PRKA) anchor protein 7provided by MGI
    Primary source
    MGI:MGI:1859150
    See related
    Ensembl:ENSMUSG00000039166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aka; AKAP15; Akap18; AI662165; BB170514; 6430401D08
    Expression
    Broad expression in cerebellum adult (RPKM 6.0), CNS E18 (RPKM 4.9) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Akap7 in Genome Data Viewer
    Location:
    10; 10 A4
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (25044988..25175115, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (25169090..25299217, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (24888896..25018969, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene actin, gamma, cytoplasmic 1 pseudogene Neighboring gene predicted gene, 36313 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene predicted gene, 25016 Neighboring gene predicted gene, 40617 Neighboring gene erythrocyte membrane protein band 4.1 like 2 Neighboring gene small leucine-rich protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables AMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase A binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein kinase A regulatory subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein kinase A regulatory subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in exocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    A-kinase anchor protein 7
    Names
    A-kinase anchor protein 18
    A-kinase anchor protein 9 kDa
    AKAP 9
    AKAP-18
    protein kinase A anchoring protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347460.2NP_001334389.1  A-kinase anchor protein 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153549
      Consensus CDS
      CCDS83688.1
      UniProtKB/Swiss-Prot
      O55074
      Related
      ENSMUSP00000097590.3, ENSMUST00000100012.3
      Conserved Domains (1) summary
      pfam10470
      Location:2379
      AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
    2. NM_001379238.1NP_001366167.1  A-kinase anchor protein 7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AC153549, AC153550
      Conserved Domains (2) summary
      pfam10470
      Location:256311
      AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
      pfam10469
      Location:51249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    3. NM_001379239.1NP_001366168.1  A-kinase anchor protein 7 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (3).
      Source sequence(s)
      AC153549, AC153550
      Conserved Domains (1) summary
      pfam10469
      Location:51249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    4. NM_001379240.1NP_001366169.1  A-kinase anchor protein 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153550
      Related
      ENSMUSP00000093455.5, ENSMUST00000095779.11
    5. NM_018747.5NP_061217.3  A-kinase anchor protein 7 isoform 1

      See identical proteins and their annotated locations for NP_061217.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variant 3, encodes isoform 1.
      Source sequence(s)
      AC153549, AC153550
      Consensus CDS
      CCDS23753.1
      UniProtKB/Swiss-Prot
      Q7TN79
      Related
      ENSMUSP00000043624.8, ENSMUST00000041984.14
      Conserved Domains (2) summary
      pfam10470
      Location:256311
      AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
      pfam10469
      Location:51249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    RNA

    1. NR_166567.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153549, AC153550
    2. NR_166568.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153549, AC153550
    3. NR_166569.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC153549

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      25044988..25175115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512788.4XP_006512851.1  A-kinase anchor protein 7 isoform X2

      See identical proteins and their annotated locations for XP_006512851.1

      Conserved Domains (1) summary
      pfam10469
      Location:51249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    2. XM_030245157.2XP_030101017.1  A-kinase anchor protein 7 isoform X3

      Conserved Domains (2) summary
      pfam10470
      Location:256311
      AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
      pfam10469
      Location:51249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    3. XM_030245156.1XP_030101016.1  A-kinase anchor protein 7 isoform X2

      Conserved Domains (1) summary
      pfam10469
      Location:51249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    4. XM_006512790.3XP_006512853.1  A-kinase anchor protein 7 isoform X2

      See identical proteins and their annotated locations for XP_006512853.1

      Conserved Domains (1) summary
      pfam10469
      Location:51249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    5. XM_036155887.1XP_036011780.1  A-kinase anchor protein 7 isoform X2

      Conserved Domains (1) summary
      pfam10469
      Location:51249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    6. XM_006512789.2XP_006512852.1  A-kinase anchor protein 7 isoform X2

      See identical proteins and their annotated locations for XP_006512852.1

      Conserved Domains (1) summary
      pfam10469
      Location:51249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    7. XM_006512791.5XP_006512854.1  A-kinase anchor protein 7 isoform X2

      See identical proteins and their annotated locations for XP_006512854.1

      Conserved Domains (1) summary
      pfam10469
      Location:51249
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    8. XM_006512793.5XP_006512856.1  A-kinase anchor protein 7 isoform X4

      See identical proteins and their annotated locations for XP_006512856.1

      Conserved Domains (1) summary
      pfam10469
      Location:6164
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    9. XM_006512794.5XP_006512857.1  A-kinase anchor protein 7 isoform X4

      See identical proteins and their annotated locations for XP_006512857.1

      Conserved Domains (1) summary
      pfam10469
      Location:6164
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
    10. XM_017314023.3XP_017169512.1  A-kinase anchor protein 7 isoform X5

      Conserved Domains (1) summary
      pfam10470
      Location:46102
      AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
    11. XM_036155886.1XP_036011779.1  A-kinase anchor protein 7 isoform X1

      Conserved Domains (1) summary
      pfam10469
      Location:187385
      AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

    RNA

    1. XR_001779549.3 RNA Sequence

    2. XR_003948725.2 RNA Sequence

    3. XR_001779547.3 RNA Sequence

    4. XR_001779546.3 RNA Sequence

    5. XR_380068.5 RNA Sequence

    6. XR_380067.3 RNA Sequence

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