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    Osbp Oxysterol binding protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42985, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Osbpprovided by FlyBase
    Official Full Name
    Oxysterol binding proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020626
    Locus tag
    Dmel_CG6708
    See related
    AllianceGenome:FB:FBgn0020626
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6708; Dmel\CG6708; osbp; OSBP; OSBP-Dm
    Summary
    Predicted to enable sterol binding activity and sterol transporter activity. Involved in Golgi organization; intracellular protein transport; and sperm individualization. Located in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including embryonic Malpighian tubule; embryonic/larval crystal cell; foregut primordium; germ layer derivative; and gut section. Orthologous to human OSBP (oxysterol binding protein) and OSBP2 (oxysterol binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    96B10-96B10; 3-86 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24934869..24938222, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20760591..20763944, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46097 Neighboring gene Mitotic spindle and nuclear protein Neighboring gene Topoisomerase related function 4-2 Neighboring gene uncharacterized protein Neighboring gene slingshot Neighboring gene Nicotinamide mononucleotide adenylyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cellular homeostasis in the Drosophila retina requires the lipid phosphatase Sac1. Griffiths NW, et al. Mol Biol Cell, 2020 May 15. PMID 32186963, Free PMC Article
    2. The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control. Moustaqim-Barrette A, et al. Hum Mol Genet, 2014 Apr 15. PMID 24271015, Free PMC Article
    3. A Drosophila homologue of oxysterol binding protein (OSBP)--implications for the role of OSBP. Alphey L, et al. Biochim Biophys Acta, 1998 Jan 21. PMID 9473651
    4. Case studies of ends-out gene targeting in Drosophila. Chen H, et al. Genesis, 2009 May. PMID 19298016
    5. The cholesterol trafficking protein NPC1 is required for Drosophila spermatogenesis. Wang C, et al. Dev Biol, 2011 Mar 1. PMID 21215267

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study identified an OSBP- and FAN-mediated sterol requirement in Drosophila spermatogenesis
      Title: OSBP- and FAN-mediated sterol requirement for spermatogenesis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in perinuclear endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol binding protein
    Names
    CG6708-PA
    Osbp-PA
    oxysterol-binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24934869..24938222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057923.4 → NP_477271.1  oxysterol binding protein [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477271.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18397, Q9VC05
      Related
      FBpp0084176
      Conserved Domains (3) summary
      cd13284
      Location:17 → 113
      PH_OSBP_ORP4; Human Oxysterol binding protein and OSBP-related protein 4 Pleckstrin homology (PH) domain
      pfam00169
      Location:15 → 107
      PH; PH domain
      pfam01237
      Location:399 → 764
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18397 O18397
    Q9VC05 Q9VC05

    Gene LinkOut

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