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    KMT2A lysine methyltransferase 2A [ Homo sapiens (human) ]

    Gene ID: 4297, updated on 5-May-2024

    Summary

    Official Symbol
    KMT2Aprovided by HGNC
    Official Full Name
    lysine methyltransferase 2Aprovided by HGNC
    Primary source
    HGNC:HGNC:7132
    See related
    Ensembl:ENSG00000118058 MIM:159555; AllianceGenome:HGNC:7132
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HRX; MLL; ALL1; GAS7; HTRX; MLL1; TRX1; ALL-1; CXXC7; HTRX1; MLL1A; WDSTS
    Summary
    This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
    Expression
    Ubiquitous expression in ovary (RPKM 12.8), lymph node (RPKM 6.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KMT2A in Genome Data Viewer
    Location:
    11q23.3
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (118436492..118526832)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (118455794..118546121)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118307207..118397547)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5590 Neighboring gene ubiquitination factor E4A Neighboring gene uncharacterized LOC100131626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5591 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:118272182-118273045 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:118273504-118274094 Neighboring gene ATP synthase membrane subunit g Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr11:118306179-118307176 and GRCh37_chr11:118307177-118308175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:118308176-118309173 Neighboring gene Sharpr-MPRA regulatory region 11577 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:118358704-118358932 Neighboring gene TTC36 and KMT2A antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 12917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3947 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene transmembrane protein 25 Neighboring gene intraflagellar transport 46

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Wiedemann-Steiner syndrome
    MedGen: C1854630 OMIM: 605130 GeneReviews: Wiedemann-Steiner Syndrome
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2018-05-23)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2018-05-23)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol The IN catalytic core domain has a higher binding affinity (Kd) for PSIP1 (LEDGF/p75) than the physiological binding partner, KMT2A (MML1) PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ11783

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K4 methyltransferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables histone H3K4 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K4 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K4 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3K4 methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables histone H3K4 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K4 trimethyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables lysine-acetylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables minor groove of adenine-thymine-rich DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-cysteine methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables unmethylated CpG binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in T-helper 2 cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in definitive hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic hemopoiesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in exploration behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in homeostasis of number of cells within a tissue IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA methylation-dependent heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein modification process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of short-term neuronal synaptic plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to potassium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spleen development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription initiation-coupled chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transcription initiation-coupled chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in visual learning IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of MLL1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MLL1 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of histone methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase 2A
    Names
    Acute lymphocytic 1
    CXXC-type zinc finger protein 7
    lysine (K)-specific methyltransferase 2A
    lysine N-methyltransferase 2A
    mixed lineage leukemia 1
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
    trithorax-like protein
    zinc finger protein HRX
    NP_001184033.1
    NP_001399526.1
    NP_005924.2
    XP_006718902.2
    XP_011541131.1
    XP_011541132.1
    XP_011541135.1
    XP_047282919.1
    XP_047282920.1
    XP_054224805.1
    XP_054224806.1
    XP_054224807.1
    XP_054224808.1
    XP_054224809.1
    XP_054224810.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027813.1 RefSeqGene

      Range
      5001..95335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_613

    mRNA and Protein(s)

    1. NM_001197104.2NP_001184033.1  histone-lysine N-methyltransferase 2A isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (1) has the same N- and C-termini but is shorter compared to isoform 3.
      Source sequence(s)
      AI500057, AP000941, AP001267, BC065385, D14540, L04731
      Consensus CDS
      CCDS55791.1
      UniProtKB/TrEMBL
      A0A8I5KXR3
      Related
      ENSP00000436786.2, ENST00000534358.8
      Conserved Domains (9) summary
      cd05493
      Location:16501780
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:36723755
      FYRC; FY-rich domain, C-terminal region
      cd15588
      Location:14331479
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:14811530
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:15681627
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:18741986
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam02008
      Location:11471194
      zf-CXXC; CXXC zinc finger domain
      pfam05964
      Location:20272074
      FYRN; F/Y-rich N-terminus
      cd19170
      Location:38193972
      SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins
    2. NM_001412597.1NP_001399526.1  histone-lysine N-methyltransferase 2A isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AP000941, AP001267
      UniProtKB/TrEMBL
      A0AA34QVI8
      Related
      ENSP00000518343.1, ENST00000710560.1
    3. NM_005933.4NP_005924.2  histone-lysine N-methyltransferase 2A isoform 2 precursor

      See identical proteins and their annotated locations for NP_005924.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 3. This results in a shorter protein (isoform 2), compared to isoform 3.
      Source sequence(s)
      AB209508, AP000941, AP001267, BC065385, D14540
      Consensus CDS
      CCDS31686.1
      UniProtKB/Swiss-Prot
      E9PQG7, Q03164, Q13743, Q13744, Q14845, Q16364, Q59FF2, Q6UBD1, Q9HBJ3, Q9UD94, Q9UMA3
      UniProtKB/TrEMBL
      A0A8I5KXR3
      Related
      ENSP00000374157.5, ENST00000389506.10
      Conserved Domains (11) summary
      cd05493
      Location:16471777
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:36693752
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:38313951
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:39533969
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:38253969
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam02008
      Location:11471194
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:14331479
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:14811530
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:15681624
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:18711983
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:20252071
      FYRN; F/Y-rich N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      118436492..118526832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542829.3XP_011541131.1  histone-lysine N-methyltransferase 2A isoform X1

      UniProtKB/TrEMBL
      A0A8I5KXR3, E9PR05
      Related
      ENSP00000432391.3, ENST00000531904.7
      Conserved Domains (11) summary
      cd05493
      Location:16831813
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:37053788
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:38673987
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:39894005
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:38614005
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam02008
      Location:11801227
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:14661512
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:15141563
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:16011660
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:19072019
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:20612107
      FYRN; F/Y-rich N-terminus
    2. XM_011542830.3XP_011541132.1  histone-lysine N-methyltransferase 2A isoform X2

      UniProtKB/TrEMBL
      A0A8I5KXR3
      Conserved Domains (11) summary
      cd05493
      Location:16821812
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:37043787
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:38663986
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:39884004
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:38604004
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam02008
      Location:11801227
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:14661512
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:15141562
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:16001659
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:19062018
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:20602106
      FYRN; F/Y-rich N-terminus
    3. XM_047426963.1XP_047282919.1  histone-lysine N-methyltransferase 2A isoform X3

    4. XM_011542833.3XP_011541135.1  histone-lysine N-methyltransferase 2A isoform X4

      Conserved Domains (11) summary
      cd05493
      Location:844974
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:28662949
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:30283148
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:31503166
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:30143166
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam02008
      Location:341388
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:627673
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:675724
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:762821
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:10681180
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:12221268
      FYRN; F/Y-rich N-terminus
    5. XM_006718839.4XP_006718902.2  histone-lysine N-methyltransferase 2A isoform X5

      Conserved Domains (11) summary
      cd05493
      Location:811941
      Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
      smart00542
      Location:28332916
      FYRC; FY-rich domain, C-terminal region
      smart00317
      Location:29953115
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:31173133
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:29813133
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam02008
      Location:308355
      zf-CXXC; CXXC zinc finger domain
      cd15588
      Location:594640
      PHD1_KMT2A; PHD finger 1 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15590
      Location:642691
      PHD2_KMT2A; PHD finger 2 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15592
      Location:729788
      PHD3_KMT2A; PHD finger 3 found in histone-lysine N-methyltransferase 2A (KMT2A)
      cd15693
      Location:10351147
      ePHD_KMT2A; Extended PHD finger found in histone-lysine N-methyltransferase 2A (KMT2A)
      pfam05964
      Location:11891235
      FYRN; F/Y-rich N-terminus
    6. XM_047426964.1XP_047282920.1  histone-lysine N-methyltransferase 2A isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      118455794..118546121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368830.1XP_054224805.1  histone-lysine N-methyltransferase 2A isoform X1

      UniProtKB/TrEMBL
      E9PR05
    2. XM_054368831.1XP_054224806.1  histone-lysine N-methyltransferase 2A isoform X2

    3. XM_054368832.1XP_054224807.1  histone-lysine N-methyltransferase 2A isoform X3

    4. XM_054368833.1XP_054224808.1  histone-lysine N-methyltransferase 2A isoform X4

    5. XM_054368834.1XP_054224809.1  histone-lysine N-methyltransferase 2A isoform X5

    6. XM_054368835.1XP_054224810.1  histone-lysine N-methyltransferase 2A isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_024891.2: Suppressed sequence

      Description
      NM_024891.2: This RefSeq was permanently suppressed because it is primarily intronic sequence.