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    CIITA class II major histocompatibility complex transactivator [ Homo sapiens (human) ]

    Gene ID: 4261, updated on 8-Jul-2021

    Summary

    Official Symbol
    CIITAprovided by HGNC
    Official Full Name
    class II major histocompatibility complex transactivatorprovided by HGNC
    Primary source
    HGNC:HGNC:7067
    See related
    Ensembl:ENSG00000179583 MIM:600005
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C2TA; NLRA; MHC2TA; CIITAIV
    Summary
    This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
    Expression
    Broad expression in spleen (RPKM 12.7), lymph node (RPKM 11.9) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CIITA in Genome Data Viewer
    Location:
    16p13.13
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (10866208..10941562)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (10971055..11030251)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nucleotide binding protein 1 Neighboring gene trans-golgi network vesicle protein 23 homolog A Neighboring gene uncharacterized LOC105371080 Neighboring gene Rho GTPase activating protein 21 pseudogene Neighboring gene uncharacterized LOC112267907 Neighboring gene C-type lectin domain containing 16A Neighboring gene Dexi homolog Neighboring gene ribosomal protein L7 pseudogene 46 Neighboring gene uncharacterized LOC105371081

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Bare lymphocyte syndrome 2
    MedGen: C2931418 OMIM: 209920 GeneReviews: Not available
    Compare labs
    Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
    GeneReviews: Not available
    Multiple common variants for celiac disease influencing immune gene expression.
    GeneReviews: Not available
    Rheumatoid arthritis
    MedGen: C0003873 OMIM: 180300 GeneReviews: Not available
    Compare labs

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env CIITA-mediated enhancement of HIV-1 infection is gp120/gp41/CD4-dependent and occurs at the early steps in the infection cycle PubMed
    Envelope transmembrane glycoprotein gp41 env CIITA-mediated enhancement of HIV-1 infection is gp120/gp41/CD4-dependent and occurs at the early steps in the infection cycle PubMed
    Gag-Pol gag-pol CIITA increases the viral protease activity through increased HIV-1 Gag-Pol levels PubMed
    Pr55(Gag) gag CIITA enhancement of HIV-1 Gag processing is through the viral protease activity PubMed
    gag Gag production is significantly increased by fusing HIV-1-infected CD4- and CXCR4-expressing rat fibroblasts with uninfected human T-, B-, and macrophage cell lines. This process is regulated by HP68 and MHC class II transactivator (CIITA) PubMed
    Tat tat HIV-1 Tat transactivation is inhibited by the amino acids 64-285 in CIITA in U937 cells PubMed
    tat The HLA class II transcriptional activator, CIITA, inhibits HIV-1 Tat and virus replication PubMed
    tat HIV-1 Tat inhibits CIITA by competing with CIITA for binding to P-TEFb PubMed
    tat HIV-1 Tat downregulates expression of MHC class II genes in antigen-presenting cells (APC) by inhibiting the transactivator of MHC class II genes, CIITA PubMed
    capsid gag p24 production is significantly increased by fusing HIV-1-infected CD4- and CXCR4-expressing rat fibroblasts with uninfected human T-, B-, and macrophage cell lines. This process is regulated by HP68 and MHC class II transactivator (CIITA) PubMed
    retropepsin gag-pol CIITA enhancement of HIV-1 Gag processing is through the viral protease activity, which results from increased levels of HIV-1 Gag-Pol by CIITA PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coactivator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in immune response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of collagen biosynthetic process IC
    Inferred by Curator
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MHC class I biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of MHC class I biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MHC class II biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of MHC class II biosynthetic process IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to antibiotic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to interferon-gamma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    MHC class II transactivator
    Names
    MHC class II transactivator type I
    MHC class II transactivator type III
    NLR family, acid domain containing
    nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
    NP_000237.2
    NP_001273331.1
    NP_001273332.1
    NP_001366259.1
    NP_001366260.1
    NP_001366261.1
    NP_001366262.1
    NP_001366263.1
    XP_006720943.2
    XP_011520786.1
    XP_011520787.1
    XP_011520788.1
    XP_011520789.1
    XP_011520791.1
    XP_011520792.1
    XP_011520793.1
    XP_011520796.1
    XP_024306048.1
    XP_024306049.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009628.1 RefSeqGene

      Range
      5001..52786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_49

    mRNA and Protein(s)

    1. NM_000246.4NP_000237.2  MHC class II transactivator isoform 2

      See identical proteins and their annotated locations for NP_000237.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC133065, KF459560
      Consensus CDS
      CCDS10544.1
      UniProtKB/Swiss-Prot
      P33076
      UniProtKB/TrEMBL
      A0A0B4J1S1, Q66X48
      Related
      ENSP00000316328.8, ENST00000324288.14
      Conserved Domains (4) summary
      cd00116
      Location:7891114
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:9891016
      LRR_1; leucine-rich repeat [structural motif]
      sd00034
      Location:10711101
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:414583
      NACHT; NACHT domain
    2. NM_001286402.1NP_001273331.1  MHC class II transactivator isoform 1

      See identical proteins and their annotated locations for NP_001273331.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC133065, BC007406, BE247223, BM193016
      Consensus CDS
      CCDS73826.1
      UniProtKB/TrEMBL
      A0A087X2I7
      Related
      ENSP00000485010.1, ENST00000618327.4
      Conserved Domains (4) summary
      cd00116
      Location:7901115
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:9901017
      LRR_1; leucine-rich repeat [structural motif]
      sd00034
      Location:10721102
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:415584
      NACHT; NACHT domain
    3. NM_001286403.2NP_001273332.1  MHC class II transactivator isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses two alternate splice junctions and lacks two alternate coding exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC133065, AY084054, BC007406, BE247223, BM193016
      Consensus CDS
      CCDS66943.1
      UniProtKB/Swiss-Prot
      P33076
      Related
      ENSP00000371257.5, ENST00000381835.9
      Conserved Domains (2) summary
      cd00116
      Location:299530
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:402429
      LRR_AMN1; leucine-rich repeat [structural motif]
    4. NM_001379330.1NP_001366259.1  MHC class II transactivator isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC133065
      Conserved Domains (4) summary
      cd00116
      Location:7411066
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:941968
      LRR_1; leucine-rich repeat [structural motif]
      sd00034
      Location:10231053
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:366535
      NACHT; NACHT domain
    5. NM_001379331.1NP_001366260.1  MHC class II transactivator isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC133065
      Conserved Domains (4) summary
      cd00116
      Location:7401065
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:940967
      LRR_1; leucine-rich repeat [structural motif]
      sd00034
      Location:10221052
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:365534
      NACHT; NACHT domain
    6. NM_001379332.1NP_001366261.1  MHC class II transactivator isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC133065, KF459560
      Conserved Domains (4) summary
      cd00116
      Location:7901115
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:9901017
      LRR_1; leucine-rich repeat [structural motif]
      sd00034
      Location:10721102
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:415584
      NACHT; NACHT domain
    7. NM_001379333.1NP_001366262.1  MHC class II transactivator isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC133065, KF459560
      Conserved Domains (4) summary
      cd00116
      Location:7891114
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:9891016
      LRR_1; leucine-rich repeat [structural motif]
      sd00034
      Location:10711101
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:414583
      NACHT; NACHT domain
    8. NM_001379334.1NP_001366263.1  MHC class II transactivator isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC133065, KF459560
      Conserved Domains (3) summary
      cd00116
      Location:7661091
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:963990
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:391560
      NACHT; NACHT domain

    RNA

    1. NR_104444.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC133065, AY084054, BC007406, BE247223, BM193016, U31931, X74301

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      10866208..10941562
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522486.2XP_011520788.1  MHC class II transactivator isoform X3

      Conserved Domains (3) summary
      cd00116
      Location:8881149
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:10881115
      LRR_1; leucine-rich repeat [structural motif]
      pfam05729
      Location:513682
      NACHT; NACHT domain
    2. XM_011522491.2XP_011520793.1  MHC class II transactivator isoform X9

      Conserved Domains (2) summary
      cd00116
      Location:8881119
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam05729
      Location:513682
      NACHT; NACHT domain
    3. XM_011522485.2XP_011520787.1  MHC class II transactivator isoform X1

      See identical proteins and their annotated locations for XP_011520787.1

      Conserved Domains (3) summary
      cd00116
      Location:8881213
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:10851112
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:513682
      NACHT; NACHT domain
    4. XM_006720880.3XP_006720943.2  MHC class II transactivator isoform X1

      See identical proteins and their annotated locations for XP_006720943.2

      Conserved Domains (3) summary
      cd00116
      Location:8881213
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:10851112
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:513682
      NACHT; NACHT domain
    5. XM_011522484.3XP_011520786.1  MHC class II transactivator isoform X1

      See identical proteins and their annotated locations for XP_011520786.1

      Conserved Domains (3) summary
      cd00116
      Location:8881213
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:10851112
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:513682
      NACHT; NACHT domain
    6. XM_011522494.2XP_011520796.1  MHC class II transactivator isoform X12

      Conserved Domains (3) summary
      cd00116
      Location:7661091
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:963990
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:391560
      NACHT; NACHT domain
    7. XM_011522487.2XP_011520789.1  MHC class II transactivator isoform X5

      Conserved Domains (3) summary
      cd00116
      Location:8061131
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:10031030
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:431600
      NACHT; NACHT domain
    8. XM_011522489.2XP_011520791.1  MHC class II transactivator isoform X7

      Conserved Domains (3) summary
      cd00116
      Location:8051130
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:10021029
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:430599
      NACHT; NACHT domain
    9. XM_024450281.1XP_024306049.1  MHC class II transactivator isoform X4

      Conserved Domains (4) summary
      cd00116
      Location:8211146
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:10211048
      LRR_1; leucine-rich repeat [structural motif]
      sd00034
      Location:11031133
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:446615
      NACHT; NACHT domain
    10. XM_024450280.1XP_024306048.1  MHC class II transactivator isoform X2

      Conserved Domains (4) summary
      cd00116
      Location:8701195
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:10701097
      LRR_1; leucine-rich repeat [structural motif]
      sd00034
      Location:11521182
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:495664
      NACHT; NACHT domain
    11. XM_011522490.2XP_011520792.1  MHC class II transactivator isoform X8

      Conserved Domains (3) summary
      cd00116
      Location:8041129
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:10011028
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:429598
      NACHT; NACHT domain

    RNA

    1. XR_001751904.1 RNA Sequence

    2. XR_932846.3 RNA Sequence

    3. XR_932847.3 RNA Sequence

    4. XR_932842.2 RNA Sequence

    5. XR_932841.3 RNA Sequence

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