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    CG11779 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42298, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG11779provided by FlyBase
    Primary source
    FLYBASE:FBgn0038683
    Locus tag
    Dmel_CG11779
    See related
    AllianceGenome:FB:FBgn0038683
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM03811; BEST:GM03811; CG117799; Dmel\CG11779; GH-18370
    Summary
    Predicted to enable chaperone binding activity. Involved in cellular response to hypoxia. Predicted to be part of PAM complex, Tim23 associated import motor. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head and adult heart. Orthologous to human TIMM44 (translocase of inner mitochondrial membrane 44). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CG11779 in Genome Data Viewer
    Location:
    91F4-91F4; 3-66 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19154097..19159878, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14979819..14985600, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Phosphopantothenoylcysteine synthetase Neighboring gene antisense RNA:CR44107 Neighboring gene uncharacterized protein Neighboring gene nanos Neighboring gene Nop2/Sun-like domain containing protein 5 Neighboring gene uncharacterized protein Neighboring gene squeeze

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cyp12a4 confers lufenuron resistance in a natural population of Drosophila melanogaster. Bogwitz MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 6. PMID 16120680, Free PMC Article
    2. Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival. Creagh EM, et al. PLoS One, 2009. PMID 19330035, Free PMC Article
    3. Identifying susceptibility genes for primary ovarian insufficiency on the high-risk genetic background of a fragile X premutation. Trevino CE, et al. Fertil Steril, 2021 Sep. PMID 34016428, Free PMC Article
    4. An RNA interference screen identifies a novel regulator of target of rapamycin that mediates hypoxia suppression of translation in Drosophila S2 cells. Lee SJ, et al. Mol Biol Cell, 2008 Oct. PMID 18653470, Free PMC Article
    5. Lsd1 restricts the number of germline stem cells by regulating multiple targets in escort cells. Eliazer S, et al. PLoS Genet, 2014 Mar. PMID 24625679, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-folding chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of PAM complex, Tim23 associated import motor ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11779-PA
    CG11779-PB
    CG11779-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19154097..19159878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169849.2 → NP_732403.1  uncharacterized protein Dmel_CG11779, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732403.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP57, Q9VDZ8
      Related
      FBpp0083164
      Conserved Domains (2) summary
      TIGR00984
      Location:47 → 418
      3a0801s03tim44; mitochondrial import inner membrane, translocase subunit
      pfam04280
      Location:273 → 421
      Tim44; Tim44-like domain

    2. NM_001032022.2 → NP_001027193.2  uncharacterized protein Dmel_CG11779, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027193.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QP57, Q9VDZ8
      Conserved Domains (2) summary
      TIGR00984
      Location:47 → 418
      3a0801s03tim44; mitochondrial import inner membrane, translocase subunit
      pfam04280
      Location:273 → 421
      Tim44; Tim44-like domain

    3. NM_142529.3 → NP_650786.2  uncharacterized protein Dmel_CG11779, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650786.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHE3, Q9VDZ7
      Related
      FBpp0083163
      Conserved Domains (2) summary
      TIGR00984
      Location:78 → 449
      3a0801s03tim44; mitochondrial import inner membrane, translocase subunit
      pfam04280
      Location:304 → 452
      Tim44; Tim44-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IHE3 Q8IHE3
    Q95SB6 Q95SB6
    Q95U00 Q95U00
    Q9VDZ7 Q9VDZ7
    Q9VDZ8 Q9VDZ8

    Gene LinkOut

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