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    Atg8b Autophagy-related 8b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42132, updated on 8-Oct-2018

    Summary

    Official Symbol
    Atg8bprovided by FlyBase
    Official Full Name
    Autophagy-related 8bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038539
    Locus tag
    Dmel_CG12334
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Atg8; ATG8; atg8b; atg8B; Atg8B; ATG8b; CG12334; dAtg8b; Dmel\CG12334

    Genomic context

    See Atg8b in Genome Data Viewer
    Location:
    90C2-90C2; 3-61 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17724410..17725063, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13550146..13550766, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene osa Neighboring gene ncRNA Neighboring gene Peroxinectin-like Neighboring gene Leucine-rich repeat-containing G protein-coupled receptor 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Pathways from BioSystems

    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - other, organism-specific biosystem (from KEGG)
      Autophagy - other, organism-specific biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
    • Autophagy - other, conserved biosystem (from KEGG)
      Autophagy - other, conserved biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • FoxO signaling pathway, organism-specific biosystem (from KEGG)
      FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
    • Macroautophagy, organism-specific biosystem (from REACTOME)
      Macroautophagy, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Mitophagy - animal, organism-specific biosystem (from KEGG)
      Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
    • Mitophagy - animal, conserved biosystem (from KEGG)
      Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
    • TBC/RABGAPs, organism-specific biosystem (from REACTOME)
      TBC/RABGAPs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    GABA receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein tag ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    macroautophagy IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    autophagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    Autophagy-related 8b
    Names
    Atg8b-PA
    Atg8b-PB
    CG12334-PA
    CG12334-PB
    autophagy related gene 8
    autophagy-specific gene 8b

    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17724410..17725063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316551.1NP_001303480.1  Autophagy-related 8b, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEG5
      Related
      FBpp0312339, FBtr0346730
      Conserved Domains (1) summary
      cd01611
      Location:7118
      GABARAP; Ubiquitin domain of GABA-receptor-associated protein
    2. NM_142392.3NP_650649.1  Autophagy-related 8b, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650649.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VEG5
      Related
      FBpp0082957, FBtr0083533
      Conserved Domains (1) summary
      cd01611
      Location:7118
      GABARAP; Ubiquitin domain of GABA-receptor-associated protein
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