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    glob1 globin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41930, updated on 4-Apr-2024

    Summary

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    Official Symbol
    glob1provided by FlyBase
    Official Full Name
    globin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0027657
    Locus tag
    Dmel_CG9734
    See related
    AllianceGenome:FB:FBgn0027657
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9734; DmeGb1; dmeglob1; DmeGlob1; Dmel\CG9734; DmHb; DmHb1; DroHb; Glob1; globin1; Hb
    Summary
    Enables iron ion binding activity and oxygen binding activity. Predicted to be involved in oxygen transport. Located in plasma membrane. Is expressed in several structures, including extended germ band embryo; gonad; gut section; imaginal disc; and yolk sac. Human ortholog(s) of this gene implicated in several diseases, including acute chest syndrome; acute kidney failure; hemolytic anemia (multiple); polycythemia (multiple); and sickle cell anemia. Orthologous to several human genes including CYGB (cytoglobin). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See glob1 in Genome Data Viewer
    Location:
    89A8-89A8; 3-58 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15896926..15904643, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11722648..11730243, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Endoribonuclease U-specific

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adequate expression of Globin1 is required for development and maintenance of nervous system in Drosophila. Nisha, et al. Mol Cell Neurosci, 2019 Oct. PMID 31472221
    2. Thermal Stability of Globins: Implications of Flexibility and Heme Coordination Studied by Molecular Dynamics Simulations. Julió Plana L, et al. J Chem Inf Model, 2019 Jan 28. PMID 30516994
    3. Drosophila glob1 is required for the maintenance of cytoskeletal integrity during oogenesis. Yadav R, et al. Dev Dyn, 2016 Nov. PMID 27503269
    4. Analysis of Mitochondrial haemoglobin in Parkinson's disease brain. Shephard F, et al. Mitochondrion, 2016 Jul. PMID 27181046, Free PMC Article
    5. Knockdown of Drosophila hemoglobin suggests a role in O2 homeostasis. Gleixner E, et al. Insect Biochem Mol Biol, 2016 May. PMID 27001071

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of glob1 mitigates human tau mediated neurotoxicity by restricting heterochromatin loss and elevating the autophagic response in drosophila.
      Title: Downregulation of glob1 mitigates human tau mediated neurotoxicity by restricting heterochromatin loss and elevating the autophagic response in drosophila.
    2. Downregulation of glob1 suppresses pathogenesis of human neuronal tauopathies in Drosophila by regulating tau phosphorylation and ROS generation.
      Title: Downregulation of glob1 suppresses pathogenesis of human neuronal tauopathies in Drosophila by regulating tau phosphorylation and ROS generation.
    3. Glob1 expression is essential for neurogenesis in Drosophila. Downregulation of glob1 causes mispositioning of neuronal precursor cells and neuromuscular disabilities.
      Title: Adequate expression of Globin1 is required for development and maintenance of nervous system in Drosophila.
    4. Authors have performed a comprehensive investigation on the cellular expression profile and functional relevance of glob1 in Drosophila development.
      Title: Drosophila glob1 expresses dynamically and is required for development and oxidative stress response.
    5. Several pH-dependent low-spin ferric haem forms are identified in a frozen solution of the ferric (1)(2)(1)Cys-->Ser mutant of Drosophila melanogaster haemoglobin (DmHb1*) using electron paramagnetic resonance (EPR) techniques.
      Title: Unusual flexibility of distal and proximal histidine residues in the haem pocket of Drosophila melanogaster haemoglobin.
    6. expression levels of dmeglob1 are decreased under both short- and long-term hypoxia
      Title: Oxygen-induced changes in hemoglobin expression in Drosophila.
    7. Characterization of Drosophila hemoglobin
      Title: Characterization of Drosophila hemoglobin. Evidence for hemoglobin-mediated respiration in insects.
    8. crystal structure of recombinant D. melanogaster hemoglobin at 1.20 A resolution displays a hexacoordinated heme, whose axial ligands are the proximal and distal His residues and three protein matrix cavities
      Title: Bishistidyl heme hexacoordination, a key structural property in Drosophila melanogaster hemoglobin.
    9. molecular characterization of human and Drosophila cytoglobulins and neuroglobulins
      Title: Hyperthermal stability of neuroglobin and cytoglobin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heme binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables iron ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxygen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxygen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxygen binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables oxygen carrier activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in oxygen transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxygen transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in response to hypoxia IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    globin 1
    Names
    CG9734-PA
    CG9734-PB
    CG9734-PC
    CG9734-PD
    CG9734-PE
    CG9734-PF
    glob1-PA
    glob1-PB
    glob1-PC
    glob1-PD
    glob1-PE
    glob1-PF
    globin
    haemoglobin
    hemoglobin
    hemoglobin gene 1
    NP_001163625.1
    NP_001287343.1
    NP_524369.1
    NP_732081.1
    NP_732082.1
    NP_732083.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15896926..15904643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300414.2 → NP_001287343.1  globin 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287343.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1K3, Q9VF15
      Conserved Domains (1) summary
      cd01040
      Location:9 → 142
      Mb_like; myoglobin_like; M family globin domain

    2. NM_169679.3 → NP_732082.1  globin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732082.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1K3, Q9VF15
      Related
      FBpp0082699
      Conserved Domains (1) summary
      cd01040
      Location:9 → 142
      Mb_like; myoglobin_like; M family globin domain

    3. NM_169680.3 → NP_732083.1  globin 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732083.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1K3, Q9VF15
      Related
      FBpp0082702
      Conserved Domains (1) summary
      cd01040
      Location:9 → 142
      Mb_like; myoglobin_like; M family globin domain

    4. NM_079645.4 → NP_524369.1  globin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524369.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1K3, Q9VF15
      Related
      FBpp0082700
      Conserved Domains (1) summary
      cd01040
      Location:9 → 142
      Mb_like; myoglobin_like; M family globin domain

    5. NM_169678.2 → NP_732081.1  globin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732081.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U1K3, Q9VF15
      Related
      FBpp0082701
      Conserved Domains (1) summary
      cd01040
      Location:9 → 142
      Mb_like; myoglobin_like; M family globin domain

    6. NM_001170154.3 → NP_001163625.1  globin 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163625.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0T2
      Conserved Domains (1) summary
      cl21461
      Location:9 → 59
      Globin-like; Globin-like protein superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T0T2 Q8T0T2
    Q9U1K3 Q9U1K3
    Q9VF15 Q9VF15

    Gene LinkOut

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