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    MCM4 minichromosome maintenance complex component 4 [ Homo sapiens (human) ]

    Gene ID: 4173, updated on 8-Jul-2021

    Summary

    Official Symbol
    MCM4provided by HGNC
    Official Full Name
    minichromosome maintenance complex component 4provided by HGNC
    Primary source
    HGNC:HGNC:6947
    See related
    Ensembl:ENSG00000104738 MIM:602638
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NKCD; CDC21; CDC54; IMD54; NKGCD; hCdc21; P1-CDC21
    Summary
    The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 21.3), bone marrow (RPKM 19.5) and 24 other tissues See more
    Orthologs
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    Genomic context

    See MCM4 in Genome Data Viewer
    Location:
    8q11.21
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (47960941..47978160)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (48873501..48890720)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene protein kinase, DNA-activated, catalytic subunit Neighboring gene uncharacterized LOC105375818 Neighboring gene origin of replication upstream of MCM4 Neighboring gene uncharacterized TCONS_00068220 Neighboring gene RNA, U6 small nuclear 519, pseudogene Neighboring gene ubiquitin conjugating enzyme E2 V2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with minichromosome maintenance complex component 4 (MCM4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC33310

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to single-stranded DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CMG complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of MCM complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of MCM complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA replication licensing factor MCM4
    Names
    homolog of S. pombe cell devision cycle 21
    minichromosome maintenance deficient 4
    NP_005905.2
    NP_877423.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032967.1 RefSeqGene

      Range
      5739..22958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1239

    mRNA and Protein(s)

    1. NM_005914.4NP_005905.2  DNA replication licensing factor MCM4

      See identical proteins and their annotated locations for NP_005905.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents a longer transcript and differs in the 5' UTR, as compared to variant 2. Both variants encode the same protein.
      Source sequence(s)
      AC021236, AK296913, BC031061, BF793151, BQ689703
      Consensus CDS
      CCDS6143.1
      UniProtKB/Swiss-Prot
      P33991
      UniProtKB/TrEMBL
      B4DLA6
      Related
      ENSP00000262105.2, ENST00000262105.6
      Conserved Domains (3) summary
      smart00350
      Location:267770
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:166287
      MCM_N; MCM N-terminal domain
      cl21455
      Location:505644
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_182746.3NP_877423.1  DNA replication licensing factor MCM4

      See identical proteins and their annotated locations for NP_877423.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR, when compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AC021236, AK022899, BC031061, BQ689703
      Consensus CDS
      CCDS6143.1
      UniProtKB/Swiss-Prot
      P33991
      UniProtKB/TrEMBL
      B3KMX0
      Related
      ENSP00000496964.1, ENST00000649973.1
      Conserved Domains (3) summary
      smart00350
      Location:267770
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:166287
      MCM_N; MCM N-terminal domain
      cl21455
      Location:505644
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

      Range
      47960941..47978160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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