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    MAP1B microtubule associated protein 1B [ Homo sapiens (human) ]

    Gene ID: 4131, updated on 9-Jun-2024

    Summary

    Official Symbol
    MAP1Bprovided by HGNC
    Official Full Name
    microtubule associated protein 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:6836
    See related
    Ensembl:ENSG00000131711 MIM:157129; AllianceGenome:HGNC:6836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAP5; PVNH9; DFNA83; FUTSCH; PPP1R102
    Summary
    This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 49.2), adrenal (RPKM 7.7) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MAP1B in Genome Data Viewer
    Location:
    5q13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (72107475..72209565)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (72588652..72690733)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (71403302..71505392)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986382 Neighboring gene uncharacterized LOC124901000 Neighboring gene uncharacterized LOC105379028 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:71403221-71404203 Neighboring gene Sharpr-MPRA regulatory region 7919 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:71418105-71418608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:71453937-71454436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:71475503-71476092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22644 Neighboring gene microRNA 4803 Neighboring gene Sharpr-MPRA regulatory region 4397 Neighboring gene Sharpr-MPRA regulatory region 3458 Neighboring gene mitochondrial ribosomal protein S27 Neighboring gene uncharacterized LOC107986422 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:71597159-71598114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22646 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16079 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:71607834-71608334 Neighboring gene RNA, 7SL, cytoplasmic 153, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Hearing loss, autosomal dominant 83
    MedGen: C5676951 OMIM: 619808 GeneReviews: Not available
    not available
    Periventricular nodular heterotopia 9
    MedGen: C5394503 OMIM: 618918 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif interacts with MAP1B; interaction predicted to be relevant to proteolysis PubMed
    vif HIV-1 Vif downregulates the expression of microtubule-associated protein 1B (MAP1B) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ38954, DKFZp686E1099, DKFZp686F1345

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural molecule activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in axon extension TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to peptide hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendrite development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in developmental maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of monopolar cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in induction of synaptic plasticity by chemical substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule bundle formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrion transport along microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of intracellular transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of microtubule depolymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron migration TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within odontoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peripheral nervous system axon regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to carbohydrate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to inorganic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insecticide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to vitamin A IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synapse assembly IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in basal dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in hippocampal mossy fiber ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of microtubule associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor outer segment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    located_in somatodendritic compartment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in varicosity IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    microtubule-associated protein 1B
    Names
    protein phosphatase 1, regulatory subunit 102

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324255.2NP_001311184.1  microtubule-associated protein 1B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK125194, AK307990, BC046114, BC073993, BN001085, HY119868
      UniProtKB/TrEMBL
      A2BDK6
      Conserved Domains (1) summary
      PRK14949
      Location:14051703
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional
    2. NM_005909.5NP_005900.2  microtubule-associated protein 1B isoform 1

      See identical proteins and their annotated locations for NP_005900.2

      Status: VALIDATED

      Source sequence(s)
      AC012609, BC017240, BC046114, BN001084, CA429544
      Consensus CDS
      CCDS4012.1
      UniProtKB/Swiss-Prot
      A2BDK5, P46821
      UniProtKB/TrEMBL
      A2BDK6
      Related
      ENSP00000296755.7, ENST00000296755.12
      Conserved Domains (1) summary
      PRK14949
      Location:15311829
      PRK14949; DNA polymerase III subunits gamma and tau; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      72107475..72209565
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      72588652..72690733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032010.1: Suppressed sequence

      Description
      NM_032010.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.