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    mura murashka [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41145, updated on 4-Apr-2024

    Summary

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    Official Symbol
    muraprovided by FlyBase
    Official Full Name
    murashkaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037705
    Locus tag
    Dmel_CG9381
    See related
    AllianceGenome:FB:FBgn0037705
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9381; CG9382; Dmel\CG9381; Mura
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in behavioral response to ethanol and long-term memory. Predicted to be located in nucleus. Is expressed in anterior midgut primordium; embryonic/larval midgut; larval ventral nerve cord; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in Tonne-Kalscheuer syndrome. Orthologous to several human genes including RNF38 (ring finger protein 38). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    85D22-85D24; 3-48 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9535625..9551806, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5361347..5377528, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-2283 stem loop Neighboring gene Lysine demethylase 3 Neighboring gene blistery Neighboring gene long non-coding RNA:CR42549 Neighboring gene RNA-binding protein S1 Neighboring gene uncharacterized protein Neighboring gene Branched chain keto acid dehydrogenase E1 subunit alpha Neighboring gene Adaptor Protein complex 1, mu subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila. Cammarata-Mouchtouris A, et al. PLoS Pathog, 2020 Apr. PMID 32339205, Free PMC Article
    2. The long-term memory trace formed in the Drosophila α/β mushroom body neurons is abolished in long-term memory mutants. Akalal DB, et al. J Neurosci, 2011 Apr 13. PMID 21490205, Free PMC Article
    3. Shared visual attention and memory systems in the Drosophila brain. van Swinderen B, et al. PLoS One, 2009 Jun 19. PMID 19543525, Free PMC Article
    4. Neural substrates of memory: from synapse to system. Dubnau J, et al. J Neurobiol, 2003 Jan. PMID 12486707
    5. Waking experience affects sleep need in Drosophila. Ganguly-Fitzgerald I, et al. Science, 2006 Sep 22. PMID 16990546

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    murashka
    Names
    CG9381-PA
    CG9381-PB
    CG9381-PC
    mura-PA
    mura-PB
    mura-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9535625..9551806 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141645.4 → NP_649902.2  murashka, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649902.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX72
      Related
      FBpp0081594
      Conserved Domains (1) summary
      pfam13639
      Location:771 → 813
      zf-RING_2; Ring finger domain

    2. NM_169291.2 → NP_731366.1  murashka, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731366.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SX72
      Related
      FBpp0081595
      Conserved Domains (1) summary
      pfam13639
      Location:771 → 813
      zf-RING_2; Ring finger domain

    3. NM_169292.3 → NP_731367.2  murashka, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731367.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VHC1, Q9VHC2
      Related
      FBpp0081596
      Conserved Domains (1) summary
      pfam13639
      Location:1076 → 1118
      zf-RING_2; Ring finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SX72 Q8SX72
    Q95RL7 Q95RL7
    Q9VHC2 Q9VHC2

    Gene LinkOut

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