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    hb hunchback [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41032, updated on 11-Apr-2024

    Summary

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    Official Symbol
    hbprovided by FlyBase
    Official Full Name
    hunchbackprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001180
    Locus tag
    Dmel_CG9786
    See related
    AllianceGenome:FB:FBgn0001180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9786; Dm-hb; Dm-Hb; Dmel\CG9786; Hb; HB; hbHLH; Hunchback; l(3)85Ah; R-pbx; Rg-bx; Rg-pbx
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including generation of neurons; regulation of neural precursor cell proliferation; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including ectoderm anlage; embryonic/larval nervous system; extended germ band embryo; germ layer; and somatic precursor cell. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human IKZF5 (IKAROS family zinc finger 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    85A5-85A5; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8690980..8697822, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4516702..4523544, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44937 Neighboring gene uncharacterized protein Neighboring gene Cyclin-dependent kinase subunit 85A Neighboring gene uncharacterized protein Neighboring gene Transmembrane protein 216 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis. Foe VE, et al. J Cell Sci, 1983 May. PMID 6411748
    2. A gap gene, hunchback, regulates the spatial expression of Ultrabithorax. White RA, et al. Cell, 1986 Oct 24. PMID 2876779
    3. Identification and expression of the gap segmentation gene hunchback in Drosophila melanogaster. Bender M, et al. Dev Genet, 1988. PMID 2849517
    4. Rapid evolution of cis-regulatory sequences via local point mutations. Stone JR, et al. Mol Biol Evol, 2001 Sep. PMID 11504856
    5. Crystallization and characterization of Pumilo: a novel RNA binding protein. Edwards TA, et al. J Struct Biol, 2000 Dec. PMID 11303521

    See all (400) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Enhancer of trithorax/polycomb, Corto, regulates timing of hunchback gene relocation and competence in Drosophila neuroblasts.
      Title: Enhancer of trithorax/polycomb, Corto, regulates timing of hunchback gene relocation and competence in Drosophila neuroblasts.
    2. Structure and dynamics of the quaternary hunchback mRNA translation repression complex.
      Title: Structure and dynamics of the quaternary hunchback mRNA translation repression complex.
    3. Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships.
      Title: Temporal transcription factors determine circuit membership by permanently altering motor neuron-to-muscle synaptic partnerships.
    4. A mechanism for hunchback promoters to readout morphogenetic positional information in less than a minute.
      Title: A mechanism for hunchback promoters to readout morphogenetic positional information in less than a minute.
    5. Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci.
      Title: Neuroblast-specific open chromatin allows the temporal transcription factor, Hunchback, to bind neuroblast-specific loci.
    6. The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting in Drosophila
      Title: The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting in Drosophila.
    7. These data show Hb acts as a potent regulator of neuromuscular wiring decisions.
      Title: How prolonged expression of Hunchback, a temporal transcription factor, re-wires locomotor circuits.
    8. Bicoid-Dependent Activation of the Target Gene hunchback Requires a Two-Motif Sequence Code in a Specific Basal Promoter.
      Title: Bicoid-Dependent Activation of the Target Gene hunchback Requires a Two-Motif Sequence Code in a Specific Basal Promoter.
    9. While Hunchback directly represses the eve stripe 3+7 enhancer, study found that in the eve stripe 2+7 enhancer, Hunchback repression is prevented by nearby sequences-this phenomenon is called counter-repression.
      Title: Hunchback is counter-repressed to regulate even-skipped stripe 2 expression in Drosophila embryos.
    10. Hunchback (Hb) regulates a significant number of genes that are expressed during late differentiation stages. Hb is expressed in two polyploid subperineurial glia cells (carpet cells) and a thorough functional analysis shows that loss of Hb function results in a loss of carpet cells in the eye-antennal disc.
      Title: Dynamic genome wide expression profiling of Drosophila head development reveals a novel role of Hunchback in retinal glia cell development and blood-brain barrier integrity.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ganglion mother cell fate determination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in generation of neurons IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuroblast fate determination IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in neuroblast fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in posterior head segmentation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of development, heterochronic TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in salivary gland development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in trunk segmentation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ventral cord development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in zygotic determination of anterior/posterior axis, embryo NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in zygotic determination of anterior/posterior axis, embryo TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    hunchback
    Names
    CG9786-PA
    CG9786-PB
    Regulator-of-postbithorax
    hb-PA
    hb-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8690980..8697822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169233.2 → NP_731267.1  hunchback, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731267.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P05084, Q24018, Q29R06, Q960U7
      Related
      FBpp0081432
      Conserved Domains (3) summary
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:707 → 727
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:283 → 308
      zf-H2C2_2; Zinc-finger double domain

    2. NM_169234.2 → NP_731268.1  hunchback, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731268.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P05084, Q24018, Q29R06, Q960U7
      Related
      FBpp0081431
      Conserved Domains (3) summary
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:707 → 727
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:283 → 308
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05084.2 P05084

    Gene LinkOut

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