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    MAFG MAF bZIP transcription factor G [ Homo sapiens (human) ]

    Gene ID: 4097, updated on 5-May-2024

    Summary

    Official Symbol
    MAFGprovided by HGNC
    Official Full Name
    MAF bZIP transcription factor Gprovided by HGNC
    Primary source
    HGNC:HGNC:6781
    See related
    Ensembl:ENSG00000197063 MIM:602020; AllianceGenome:HGNC:6781
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hMAF
    Summary
    Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]
    Expression
    Ubiquitous expression in bone marrow (RPKM 12.5), brain (RPKM 8.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MAFG in Genome Data Viewer
    Location:
    17q25.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (81918270..81931244, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (82785430..82798403, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79876146..79885611, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9164 Neighboring gene phosphate cytidylyltransferase 2, ethanolamine Neighboring gene neuropeptide B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9167 Neighboring gene sirtuin 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:79875237-79876133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12984 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:79880785-79881984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:79882682-79883637 Neighboring gene MAFG antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9169 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9170 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9171 Neighboring gene MYC inducible lncRNA inactivating p53 Neighboring gene pyrroline-5-carboxylate reductase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9172 Neighboring gene myeloid associated differentiation marker like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC13090, MGC20149

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    transcription factor MafG
    Names
    basic leucine zipper transcription factor MafG
    v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002359.4NP_002350.1  transcription factor MafG

      See identical proteins and their annotated locations for NP_002350.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA775797, AC145207, BC103722, DR156847
      Consensus CDS
      CCDS11793.1
      UniProtKB/Swiss-Prot
      O15525
      Related
      ENSP00000350369.4, ENST00000357736.9
      Conserved Domains (1) summary
      cd14717
      Location:46115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain
    2. NM_032711.4NP_116100.2  transcription factor MafG

      See identical proteins and their annotated locations for NP_116100.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AA775797, AC145207, BC012327, BC103722
      Consensus CDS
      CCDS11793.1
      UniProtKB/Swiss-Prot
      O15525
      Related
      ENSP00000376173.3, ENST00000392366.7
      Conserved Domains (1) summary
      cd14717
      Location:46115
      bZIP_Maf_small; Basic leucine zipper (bZIP) domain of small musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      81918270..81931244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436070.1XP_047292026.1  transcription factor MafG isoform X1

      UniProtKB/Swiss-Prot
      O15525
    2. XM_047436071.1XP_047292027.1  transcription factor MafG isoform X1

      UniProtKB/Swiss-Prot
      O15525
    3. XM_047436072.1XP_047292028.1  transcription factor MafG isoform X1

      UniProtKB/Swiss-Prot
      O15525
    4. XM_047436068.1XP_047292024.1  transcription factor MafG isoform X1

      UniProtKB/Swiss-Prot
      O15525
    5. XM_047436069.1XP_047292025.1  transcription factor MafG isoform X1

      UniProtKB/Swiss-Prot
      O15525

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      82785430..82798403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316128.1XP_054172103.1  transcription factor MafG isoform X1

      UniProtKB/Swiss-Prot
      O15525
    2. XM_054316129.1XP_054172104.1  transcription factor MafG isoform X1

      UniProtKB/Swiss-Prot
      O15525
    3. XM_054316130.1XP_054172105.1  transcription factor MafG isoform X1

      UniProtKB/Swiss-Prot
      O15525
    4. XM_054316126.1XP_054172101.1  transcription factor MafG isoform X1

      UniProtKB/Swiss-Prot
      O15525
    5. XM_054316127.1XP_054172102.1  transcription factor MafG isoform X1

      UniProtKB/Swiss-Prot
      O15525