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    CG18249 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40964, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG18249provided by FlyBase
    Primary source
    FLYBASE:FBgn0037553
    Locus tag
    Dmel_CG18249
    See related
    AllianceGenome:FB:FBgn0037553
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT41336; Dmel\CG18249
    Summary
    Is expressed in adult head; adult heart; amnioserosa; and embryonic midgut chamber. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    84F4-84F4; 3-48 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8220146..8222188)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4045868..4047910)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Chemosensory protein A 84a Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45551 Neighboring gene long non-coding RNA:CR45550 Neighboring gene antisense RNA:CR45549 Neighboring gene DNA polymerase iota

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Altered gene regulation and synaptic morphology in Drosophila learning and memory mutants. Guan Z, et al. Learn Mem, 2011. PMID 21422168, Free PMC Article
    2. Genome-wide analyses of Shavenbaby target genes reveals distinct features of enhancer organization. Menoret D, et al. Genome Biol, 2013 Aug 23. PMID 23972280, Free PMC Article
    3. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. Palu RA, et al. PLoS Genet, 2016 Apr. PMID 27058248, Free PMC Article
    4. Phylostratigraphic bias creates spurious patterns of genome evolution. Moyers BA, et al. Mol Biol Evol, 2015 Jan. PMID 25312911, Free PMC Article
    5. A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. Neely GG, et al. Cell, 2010 Nov 12. PMID 21074052, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables potassium channel activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG18249-PB
    CG18249-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8220146..8222188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170078.2 → NP_001163549.1  uncharacterized protein Dmel_CG18249, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163549.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJ89, Q86NZ3
      Conserved Domains (3) summary
      cd00116
      Location:107 → 438
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:105 → 128
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:104 → 163
      LRR_8; Leucine rich repeat

    2. NM_141514.3 → NP_649771.1  uncharacterized protein Dmel_CG18249, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649771.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C578, Q9VHV2
      Related
      FBpp0291388
      Conserved Domains (3) summary
      cd00116
      Location:107 → 438
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:105 → 128
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:104 → 163
      LRR_8; Leucine rich repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJ89 E1JJ89
    Q86NZ3 Q86NZ3
    Q9VHV2 Q9VHV2

    Gene LinkOut

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