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    MARCKS myristoylated alanine rich protein kinase C substrate [ Homo sapiens (human) ]

    Gene ID: 4082, updated on 6-Oct-2024

    Summary

    Official Symbol
    MARCKSprovided by HGNC
    Official Full Name
    myristoylated alanine rich protein kinase C substrateprovided by HGNC
    Primary source
    HGNC:HGNC:6759
    See related
    Ensembl:ENSG00000277443 MIM:177061; AllianceGenome:HGNC:6759
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MACS; 80K-L; PKCSL; PRKCSL
    Summary
    The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 86.0), colon (RPKM 50.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MARCKS in Genome Data Viewer
    Location:
    6q21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (113857345..113863475)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (115041577..115047706)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (114178524..114184652)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L30 pseudogene 8 Neighboring gene uncharacterized LOC124901547 Neighboring gene Sharpr-MPRA regulatory region 13716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24972 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:114177679-114178224 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114178225-114178768 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:114180401-114180944 Neighboring gene MARCKS cis regulating lncRNA promoter of cytokines and inflammation Neighboring gene uncharacterized LOC124901382

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ14368, FLJ90045

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase C binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin crosslink formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neural tube development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in actin filament bundle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in focal adhesion HDA PubMed 
    located_in germinal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    myristoylated alanine-rich C-kinase substrate
    Names
    myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L)
    phosphomyristin
    protein kinase C substrate, 80 kDa protein, light chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002356.7NP_002347.5  myristoylated alanine-rich C-kinase substrate

      See identical proteins and their annotated locations for NP_002347.5

      Status: REVIEWED

      Source sequence(s)
      BC013004, BU678392, FO393415, HY144763
      Consensus CDS
      CCDS5101.1
      UniProtKB/Swiss-Prot
      E1P560, P29966, Q2LA83, Q5TDB7
      Related
      ENSP00000478061.1, ENST00000612661.2
      Conserved Domains (1) summary
      pfam02063
      Location:2322
      MARCKS; MARCKS family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      113857345..113863475
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      115041577..115047706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)