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    TM4SF1 transmembrane 4 L six family member 1 [ Homo sapiens (human) ]

    Gene ID: 4071, updated on 10-Dec-2019

    Summary

    Official Symbol
    TM4SF1provided by HGNC
    Official Full Name
    transmembrane 4 L six family member 1provided by HGNC
    Primary source
    HGNC:HGNC:11853
    See related
    Ensembl:ENSG00000169908 MIM:191155
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L6; H-L6; M3S1; TAAL6
    Summary
    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in gall bladder (RPKM 142.0), lung (RPKM 138.0) and 24 other tissues See more
    Orthologs

    Genomic context

    See TM4SF1 in Genome Data Viewer
    Location:
    3q25.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (149369022..149377781, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (149086805..149095647, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transmembrane 4 L six family member 18 Neighboring gene ribosomal protein S25 pseudogene 5 Neighboring gene TM4SF1 antisense RNA 1 Neighboring gene uncharacterized LOC105374151 Neighboring gene ribosomal protein L32 pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of transmembrane 4 L six family member 1 (TM4SF1; L6) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    molecular_function ND
    No biological Data available
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    blastocyst formation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transmembrane 4 L6 family member 1
    Names
    membrane component, chromosome 3, surface marker 1
    transmembrane 4 superfamily member 1
    tumor-associated antigen L6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014220.3NP_055035.1  transmembrane 4 L6 family member 1

      See identical proteins and their annotated locations for NP_055035.1

      Status: REVIEWED

      Source sequence(s)
      AC073522, AC108751, AK130271
      Consensus CDS
      CCDS3143.1
      UniProtKB/Swiss-Prot
      P30408
      Related
      ENSP00000304277.3, ENST00000305366.8
      Conserved Domains (1) summary
      pfam05805
      Location:1194
      L6_membrane; L6 membrane protein

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

      Range
      149369022..149377781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006385.2XP_016861874.1  transmembrane 4 L6 family member 1 isoform X1

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