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    DENND10 DENN domain containing 10 [ Homo sapiens (human) ]

    Gene ID: 404636, updated on 19-Sep-2024

    Summary

    Official Symbol
    DENND10provided by HGNC
    Official Full Name
    DENN domain containing 10provided by HGNC
    Primary source
    HGNC:HGNC:31793
    See related
    Ensembl:ENSG00000119979 AllianceGenome:HGNC:31793
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM45A
    Summary
    Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in endosome transport via multivesicular body sorting pathway; protein transport; and regulation of early endosome to late endosome transport. Located in late endosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 10.5), esophagus (RPKM 8.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DENND10 in Genome Data Viewer
    Location:
    10q26.11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (119104113..119137984)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (119999563..120033391)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120863625..120897496)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit A Neighboring gene small nucleolar RNA SNORA19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120826117-120826618 Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2867 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120840059-120840821 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120852323-120852823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120865335-120865834 Neighboring gene Sharpr-MPRA regulatory region 2644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120901959-120902460 Neighboring gene sideroflexin 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:120924677-120924863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2869 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120937203-120937847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4104 Neighboring gene peroxiredoxin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ55853

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DENN domain-containing protein 10
    Names
    family with sequence similarity 45 member A
    protein FAM45A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303111.2NP_001290040.1  DENN domain-containing protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001290040.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon and uses an alternate splice site in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK293136, AL355598, BC022271, DA531569
      UniProtKB/Swiss-Prot
      Q5H9G7, Q6NSW5, Q9NZ36
      Conserved Domains (1) summary
      pfam08616
      Location:150256
      SPA; Stabilization of polarity axis
    2. NM_001303112.2NP_001290041.1  DENN domain-containing protein 10 isoform 3

      See identical proteins and their annotated locations for NP_001290041.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate splice sites in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK297971, AL355598, BC022271, DA531569
      UniProtKB/TrEMBL
      B4DNL9
      Conserved Domains (1) summary
      pfam08616
      Location:85191
      SPA; Stabilization of polarity axis
    3. NM_001303113.2NP_001290042.1  DENN domain-containing protein 10 isoform 4

      See identical proteins and their annotated locations for NP_001290042.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site and lacks an exon in the 5' region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK297633, AL355598, BC022271, DA531569
      UniProtKB/TrEMBL
      B4DMU4
      Conserved Domains (1) summary
      pfam08616
      Location:9113
      SPA; Stabilization of polarity axis
    4. NM_207009.4NP_996892.1  DENN domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_996892.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL355598, BC022271, DA531569
      Consensus CDS
      CCDS7609.1
      UniProtKB/Swiss-Prot
      B1AMV6, B4DDC3, D3DRC8, Q5H9G7, Q6NSW5, Q8TCE6, Q9NXW4, Q9NZ36
      Related
      ENSP00000354688.2, ENST00000361432.3
      Conserved Domains (1) summary
      pfam08616
      Location:158264
      SPA; Stabilization of polarity axis

    RNA

    1. NR_130122.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK293365, AL355598, BC022271

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      119104113..119137984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717849.5XP_006717912.1  DENN domain-containing protein 10 isoform X3

      See identical proteins and their annotated locations for XP_006717912.1

      UniProtKB/TrEMBL
      A0A3B3IRE4
      Conserved Domains (1) summary
      pfam08616
      Location:47153
      SPA; Stabilization of polarity axis
    2. XM_017016264.3XP_016871753.1  DENN domain-containing protein 10 isoform X2

      UniProtKB/Swiss-Prot
      Q5H9G7, Q6NSW5, Q9NZ36
      Conserved Domains (1) summary
      pfam08616
      Location:158264
      SPA; Stabilization of polarity axis
    3. XM_047425250.1XP_047281206.1  DENN domain-containing protein 10 isoform X3

      UniProtKB/TrEMBL
      A0A3B3IRE4
    4. XM_047425251.1XP_047281207.1  DENN domain-containing protein 10 isoform X3

      UniProtKB/TrEMBL
      A0A3B3IRE4
    5. XM_047425249.1XP_047281205.1  DENN domain-containing protein 10 isoform X1

      UniProtKB/Swiss-Prot
      Q5H9G7, Q6NSW5, Q9NZ36
    6. XM_047425252.1XP_047281208.1  DENN domain-containing protein 10 isoform X3

      UniProtKB/TrEMBL
      A0A3B3IRE4
      Related
      ENSP00000496780.1, ENST00000648560.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      119999563..120033391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365945.1XP_054221920.1  DENN domain-containing protein 10 isoform X3

      UniProtKB/TrEMBL
      A0A3B3IRE4
    2. XM_054365944.1XP_054221919.1  DENN domain-containing protein 10 isoform X2

      UniProtKB/Swiss-Prot
      Q5H9G7, Q6NSW5, Q9NZ36
    3. XM_054365946.1XP_054221921.1  DENN domain-containing protein 10 isoform X3

      UniProtKB/TrEMBL
      A0A3B3IRE4
    4. XM_054365947.1XP_054221922.1  DENN domain-containing protein 10 isoform X3

      UniProtKB/TrEMBL
      A0A3B3IRE4
    5. XM_054365943.1XP_054221918.1  DENN domain-containing protein 10 isoform X1

      UniProtKB/Swiss-Prot
      Q5H9G7, Q6NSW5, Q9NZ36
    6. XM_054365948.1XP_054221923.1  DENN domain-containing protein 10 isoform X3

      UniProtKB/TrEMBL
      A0A3B3IRE4