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    KRAS KRAS proto-oncogene, GTPase [ Canis lupus familiaris (dog) ]

    Gene ID: 403871, updated on 1-Mar-2025
    Official Symbol
    KRASprovided by VGNC
    Official Full Name
    KRAS proto-oncogene, GTPaseprovided by VGNC
    Primary source
    VGNC:VGNC:42508
    See related
    Ensembl:ENSCAFG00845026771 RGD:12349413
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    K-RAS
    Orthologs
    all
    Try the new Gene page
    Try the new Transcripts and proteins table
    See KRAS in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (22456489..22495435)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (24078345..24117288, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (24245249..24284170, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (22271689..22310648)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (22290777..22329504)

    Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111092834 Neighboring gene U2 spliceosomal RNA Neighboring gene lamin tail domain containing 1 Neighboring gene ubiquitin conjugating enzyme E2 V2 pseudogene Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene U6 spliceosomal RNA Neighboring gene inositol 1,4,5-triphosphate receptor associated 2

    Go to nucleotide: Graphics FASTA GenBank

    Related articles in PubMed

    1. KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport. Schmick M, et al. Cell, 2014 Apr 10. PMID 24725411
    2. Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis. Sakurai A, et al. J Biol Chem, 2012 Sep 14. PMID 22829590, Free PMC Article
    3. K-ras activation in non-small cell lung cancer in the dog. Kraegel SA, et al. Cancer Res, 1992 Sep 1. PMID 1324792
    4. KRAS Mutations in Canine and Feline Pancreatic Acinar Cell Carcinoma. Crozier C, et al. J Comp Pathol, 2016 Jul. PMID 27290644
    5. EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR Mutation Hot Spots in Canine Intestinal Adenocarcinoma. Cho SH, et al. Vet Pathol, 2021 Jul. PMID 33926328

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR Mutation Hot Spots in Canine Intestinal Adenocarcinoma.
      Title: EGFR Overexpression and Sequence Analysis of KRAS, BRAF, and EGFR Mutation Hot Spots in Canine Intestinal Adenocarcinoma.
    2. These results delineate the signaling cascades connecting oncogenic K-Ras(V12) with alpha6- and alphaV-integrin functions to modulate cancer cell survival and tumorigenesis, and reveal new possible strategies to target highly oncogenic K-Ras(V12) mutants.
      Title: Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with αV-Class integrins to promote EMT.
    3. KRAS mutations do not play a critical role in feline or canine pancreatic acinar cell carcinomas
      Title: KRAS Mutations in Canine and Feline Pancreatic Acinar Cell Carcinoma.
    4. Study shows that the recycling endosome collects solubilized KRas from endomembranes to redirect it back to the plasma membrane.
      Title: KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport.
    5. KRAP mediates InsP(3)R clustering in confluent MDCK cells and functions as an adapter, linking InsP(3)Rs to vimentin intermediate filaments.
      Title: Vimentin and the K-Ras-induced actin-binding protein control inositol-(1,4,5)-trisphosphate receptor redistribution during MDCK cell differentiation.
    6. Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis
      Title: Activated Ras protein accelerates cell cycle progression to perturb Madin-Darby canine kidney cystogenesis.
    Submit: New GeneRIF Correction

    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GDP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Preferred Names
    GTPase KRas
    Names
    ras p21
    v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
    XP_038294636.1
    XP_038294637.1
    XP_038294638.1
    XP_038315842.1
    XP_038315843.1
    XP_038315844.1
    XP_038315845.1
    XP_038369307.1
    XP_038369308.1
    XP_038369309.1
    XP_038433017.1
    XP_038433018.1
    XP_038433019.1
    XP_038433020.1
    XP_038497105.1
    XP_038497106.1
    XP_038497107.1

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051831.1 Reference ROS_Cfam_1.0

      Range
      22456489..22495435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038438708.1 → XP_038294636.1  GTPase KRas isoform X1

      UniProtKB/TrEMBL
      A0A8C0KJX6, A0A8C0P231, A0A8I3PZB5
      Related
      ENSCAFP00845037069.1, ENSCAFT00845047233.1
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    2. XM_038438710.1 → XP_038294638.1  GTPase KRas isoform X3

      UniProtKB/TrEMBL
      A0A8C0KJX6
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    3. XM_038438709.1 → XP_038294637.1  GTPase KRas isoform X2

      UniProtKB/TrEMBL
      A0A8C0K1I4, A0A8C0KKR3, A0A8C0TJS5, A0A8C0TKU0, A0A8I3PQK0, A0A8I3Q1I3
      Related
      ENSCAFP00845037039.1, ENSCAFT00845047195.1
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049287.1 Alternate UMICH_Zoey_3.1

      Range
      22271689..22310648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038513381.1 → XP_038369309.1  GTPase KRas isoform X3

      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    2. XM_038513380.1 → XP_038369308.1  GTPase KRas isoform X2

      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    3. XM_038513379.1 → XP_038369307.1  GTPase KRas isoform X1

      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

      Range
      22290777..22329504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038641177.1 → XP_038497105.1  GTPase KRas isoform X1

      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    2. XM_038641179.1 → XP_038497107.1  GTPase KRas isoform X3

      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    3. XM_038641178.1 → XP_038497106.1  GTPase KRas isoform X2

      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

      Range
      24245249..24284170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038577091.1 → XP_038433019.1  GTPase KRas isoform X2

      UniProtKB/TrEMBL
      A0A8C0K1I4, A0A8C0KKR3, A0A8C0TJS5, A0A8C0TKU0, A0A8I3PQK0, A0A8I3Q1I3
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    2. XM_038577092.1 → XP_038433020.1  GTPase KRas isoform X3

      UniProtKB/TrEMBL
      A0A8C0KJX6
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    3. XM_038577090.1 → XP_038433018.1  GTPase KRas isoform X1

      UniProtKB/TrEMBL
      A0A8C0KJX6, A0A8C0P231, A0A8I3PZB5
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    4. XM_038577089.1 → XP_038433017.1  GTPase KRas isoform X1

      UniProtKB/TrEMBL
      A0A8C0KJX6, A0A8C0P231, A0A8I3PZB5
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      24078345..24117288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038459916.1 → XP_038315844.1  GTPase KRas isoform X2

      UniProtKB/TrEMBL
      A0A8C0K1I4, A0A8C0KKR3, A0A8C0TJS5, A0A8C0TKU0, A0A8I3PQK0, A0A8I3Q1I3
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    2. XM_038459917.1 → XP_038315845.1  GTPase KRas isoform X3

      UniProtKB/TrEMBL
      A0A8C0KJX6
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    3. XM_038459915.1 → XP_038315843.1  GTPase KRas isoform X1

      UniProtKB/TrEMBL
      A0A8C0KJX6, A0A8C0P231, A0A8I3PZB5
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

    4. XM_038459914.1 → XP_038315842.1  GTPase KRas isoform X1

      UniProtKB/TrEMBL
      A0A8C0KJX6, A0A8C0P231, A0A8I3PZB5
      Conserved Domains (1) summary
      cd04138
      Location:3 → 164
      H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B
    Nucleotide Protein
    Heading Accession and Version

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