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    LIPE lipase E, hormone sensitive type [ Homo sapiens (human) ]

    Gene ID: 3991, updated on 11-Jun-2021

    Summary

    Official Symbol
    LIPEprovided by HGNC
    Official Full Name
    lipase E, hormone sensitive typeprovided by HGNC
    Primary source
    HGNC:HGNC:6621
    See related
    Ensembl:ENSG00000079435 MIM:151750
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSL; LHS; REH; AOMS4; FPLD6
    Summary
    The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in fat (RPKM 187.4) and testis (RPKM 12.7) See more
    Orthologs
    NEW
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    Genomic context

    See LIPE in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (42401512..42427421, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42905666..42931540, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene multiple EGF like domains 8 Neighboring gene microRNA 8077 Neighboring gene uncharacterized LOC101930071 Neighboring gene LIPE antisense RNA 1 Neighboring gene cornifelin Neighboring gene C-X-C motif chemokine ligand 17 Neighboring gene RNA, U4 small nuclear 60, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1,2-diacylglycerol acylhydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 1,3-diacylglycerol acylhydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables acylglycerol lipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone-sensitive lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinyl-palmitate esterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sterol esterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables triglyceride lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in diacylglycerol catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ether lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in triglyceride catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in caveola IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    hormone-sensitive lipase
    Names
    lipase, hormone-sensitive
    monoacylglycerol lipase LIPE
    retinyl ester hydrolase
    NP_005348.2
    XP_005258994.1
    XP_005258995.1
    XP_005258996.2
    XP_005258997.1
    XP_006723281.1
    XP_016882299.1
    XP_024307282.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034246.1 RefSeqGene

      Range
      5039..30913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005357.4NP_005348.2  hormone-sensitive lipase

      See identical proteins and their annotated locations for NP_005348.2

      Status: REVIEWED

      Source sequence(s)
      AK292482, BC070041
      Consensus CDS
      CCDS12607.1
      UniProtKB/Swiss-Prot
      Q05469
      UniProtKB/TrEMBL
      A8K8W7
      Related
      ENSP00000244289.3, ENST00000244289.9
      Conserved Domains (4) summary
      COG0657
      Location:637790
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:307615
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      pfam16228
      Location:30134
      DUF4887; Domain of unknown function (DUF4887)
      cl21494
      Location:647795
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      42401512..42427421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258937.3XP_005258994.1  hormone-sensitive lipase isoform X1

      Conserved Domains (4) summary
      COG0657
      Location:637975
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:307615
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      pfam16228
      Location:30134
      DUF4887; Domain of unknown function (DUF4887)
      cl21494
      Location:647952
      Abhydrolase; alpha/beta hydrolases
    2. XM_005258938.5XP_005258995.1  hormone-sensitive lipase isoform X3

      Conserved Domains (3) summary
      COG0657
      Location:382535
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:52360
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:392540
      Abhydrolase; alpha/beta hydrolases
    3. XM_024451514.1XP_024307282.1  hormone-sensitive lipase isoform X5

      Conserved Domains (2) summary
      pfam06350
      Location:52360
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:392697
      Abhydrolase; alpha/beta hydrolases
    4. XM_006723218.3XP_006723281.1  hormone-sensitive lipase isoform X4

      See identical proteins and their annotated locations for XP_006723281.1

      UniProtKB/Swiss-Prot
      Q05469
      Conserved Domains (3) summary
      COG0657
      Location:336489
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:6314
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:346494
      Abhydrolase; alpha/beta hydrolases
    5. XM_005258939.3XP_005258996.2  hormone-sensitive lipase isoform X2

      Conserved Domains (3) summary
      COG0657
      Location:399552
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:69377
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:409557
      Abhydrolase; alpha/beta hydrolases
    6. XM_005258940.3XP_005258997.1  hormone-sensitive lipase isoform X4

      See identical proteins and their annotated locations for XP_005258997.1

      UniProtKB/Swiss-Prot
      Q05469
      Conserved Domains (3) summary
      COG0657
      Location:336489
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:6314
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:346494
      Abhydrolase; alpha/beta hydrolases
    7. XM_017026810.1XP_016882299.1  hormone-sensitive lipase isoform X4

      UniProtKB/Swiss-Prot
      Q05469
      Conserved Domains (3) summary
      COG0657
      Location:336489
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam06350
      Location:6314
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:346494
      Abhydrolase; alpha/beta hydrolases
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