LYZ lysozyme (renal amyloidosis) [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: LYZprovided by CGNC
Official Full Name: lysozyme (renal amyloidosis)provided by CGNC
Primary source: CGNC:7570
See related: Ensembl:ENSGALG00010011983
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: LYZC; dystrophin
Orthologs: human all
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Genomic context

Location:: chromosome: 1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (35550009..35553725)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (35896191..35899882)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AIE-Based Dynamic in Situ Nanoscale Visualization of Amyloid Fibrillation from Hen Egg White Lysozyme.
Title: AIE-Based Dynamic in Situ Nanoscale Visualization of Amyloid Fibrillation from Hen Egg White Lysozyme.
Lysozyme Fibrils Alter the Mechanism of Insulin Amyloid Aggregation.
Title: Lysozyme Fibrils Alter the Mechanism of Insulin Amyloid Aggregation.
Polyamines and its analogue modulates amyloid fibrillation in lysozyme: A comparative investigation.
Title: Polyamines and its analogue modulates amyloid fibrillation in lysozyme: A comparative investigation.
analysis of how lysozyme dipole-dipole interactions between tryptophan side chains and hydration water molecules dominate the observed dynamic stokes shift
Title: Dipole-dipole interactions between tryptophan side chains and hydration water molecules dominate the observed dynamic stokes shift of lysozyme.
The polyphosphate-bound, structurally destabilized egg white lysozyme molecules then start assembling into insoluble amorphous aggregates once they pass the solubility limit.
Title: Polyphosphates diminish solubility of a globular protein and thereby promote amyloid aggregation.
NG and NR inhibited the enzymatic activity of Hen Egg White Lysozyme (HEWL) and exhibited their affinity for the active site of HEWL.
Title: Binding of naringin and naringenin with hen egg white lysozyme: A spectroscopic investigation and molecular docking study.
Molecular docking results suggested the location of vandetanib (VDB) binding site near the LYZ active site while molecular dynamics simulation results suggested stability of VDB-LYZ complex.
Title: Biophysical and computational characterization of vandetanib-lysozyme interaction.
Specific structural changes constitute the first steps in lysozyme unfolding by urea.
Title: Time-dependent X-ray diffraction studies on urea/hen egg white lysozyme complexes reveal structural changes that indicate onset of denaturation.
Molecular dynamics (MD) simulation results demonstrate that the "hard protein" lysozyme retains much of its secondary structure during adsorption, whereas BSA loses it almost completely. BSA has a considerably larger adsorption energy compared to that of lysozyme, which does not scale with chain length. Desorption simulations are carried out using classical steered MD.
Title: Forced Desorption of Bovine Serum Albumin and Lysozyme from Graphite: Insights from Molecular Dynamics Simulation.
The ability of an anion to slow down the water dynamics around lysozyme was found to have the following order: SCN- > Cl- > H2PO4- > NO3- approximately SO42-. This result indicates that the effects of anions on the dynamics of water around the lysozyme molecule are the opposite of those for bulk water.
Title: Salt effects on the picosecond dynamics of lysozyme hydration water investigated by terahertz time-domain spectroscopy and an insight into the Hofmeister series for protein stability and solubility.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables lysozyme activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to Gram-positive bacterium	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: lysozyme C

Names: 1,4-beta-N-acetylmuramidase C; 4-beta-N-acetylmuramidase C; allergen Gal d IV; egg white lysozyme

NP_990612.2

EC 3.2.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.