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    JAK3 Janus kinase 3 [ Gallus gallus (chicken) ]

    Gene ID: 395845, updated on 11-Apr-2024

    Summary

    Symbol
    JAK3provided by CGNC
    Full Name
    Janus kinase 3provided by CGNC
    Primary source
    CGNC:20233
    See related
    Ensembl:ENSGALG00010027619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    JAK
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See JAK3 in Genome Data Viewer
    Location:
    chromosome: 28
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 28 NC_052559.1 (3770329..3777098, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 28 NC_052600.1 (3332775..3339538, complement)

    Chromosome 28 - NC_052559.1Genomic Context describing neighboring genes Neighboring gene FCH domain only protein 1-like Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 Neighboring gene uncharacterized LOC124417441 Neighboring gene solute carrier family 5 member 5 Neighboring gene coiled-coil domain containing 124

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    tyrosine-protein kinase JAK3
    Names
    Janus kinase 3 (a protein tyrosine kinase, leukocyte)
    NP_990327.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204996.3NP_990327.2  tyrosine-protein kinase JAK3

      Status: VALIDATED

      Source sequence(s)
      AF034576, AJ399251
      UniProtKB/TrEMBL
      O42291
      Related
      ENSGALP00010040936.1, ENSGALT00010066920.1
      Conserved Domains (7) summary
      smart00219
      Location:8221091
      TyrKc; Tyrosine kinase, catalytic domain
      cd10380
      Location:360456
      SH2_Jak3; Src homology 2 (SH2) domain in the Janus kinase 3 (Jak3) proteins
      smart00295
      Location:25255
      B41; Band 4.1 homologues
      cd05081
      Location:8171099
      PTKc_Jak3_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3
      cd14208
      Location:517778
      PTK_Jak3_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 3
      cd13334
      Location:254360
      FERM_C_JAK3; FERM domain C-lobe of Janus kinase (JAK) 3
      pfam07714
      Location:517777
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052559.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      3770329..3777098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052600.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      3332775..3339538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)