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    LECT2 leukocyte cell derived chemotaxin 2 [ Homo sapiens (human) ]

    Gene ID: 3950, updated on 27-Nov-2024

    Summary

    Official Symbol
    LECT2provided by HGNC
    Official Full Name
    leukocyte cell derived chemotaxin 2provided by HGNC
    Primary source
    HGNC:HGNC:6550
    See related
    Ensembl:ENSG00000145826 MIM:602882; AllianceGenome:HGNC:6550
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    chm2; chm-II
    Summary
    This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward liver (RPKM 110.6) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LECT2 in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (135946904..135954983, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (136469420..136477479, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (135282593..135290672, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901074 Neighboring gene interleukin 9 Neighboring gene F-box and leucine rich repeat protein 21, pseudogene Neighboring gene Sharpr-MPRA regulatory region 2274 Neighboring gene NANOG hESC enhancer GRCh37_chr5:135310975-135311476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:135337055-135337556 Neighboring gene uncharacterized LOC105379189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23177 Neighboring gene transforming growth factor beta induced Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:135388921-135390120 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16378

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126628

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal system development TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    leukocyte cell-derived chemotaxin-2
    Names
    chondromodulin-II

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002302.3NP_002293.2  leukocyte cell-derived chemotaxin-2 precursor

      See identical proteins and their annotated locations for NP_002293.2

      Status: REVIEWED

      Source sequence(s)
      AC002428
      Consensus CDS
      CCDS4190.1
      UniProtKB/Swiss-Prot
      B2RA90, O14565, O14960, Q52M49
      Related
      ENSP00000274507.1, ENST00000274507.6
      Conserved Domains (1) summary
      pfam01551
      Location:51147
      Peptidase_M23; Peptidase family M23

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      135946904..135954983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      136469420..136477479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)