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    LDHC lactate dehydrogenase C [ Homo sapiens (human) ]

    Gene ID: 3948, updated on 17-Jun-2024

    Summary

    Official Symbol
    LDHCprovided by HGNC
    Official Full Name
    lactate dehydrogenase Cprovided by HGNC
    Primary source
    HGNC:HGNC:6544
    See related
    Ensembl:ENSG00000166796 MIM:150150; AllianceGenome:HGNC:6544
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT32; LDH3; LDHX
    Summary
    Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 186.5) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LDHC in Genome Data Viewer
    Location:
    11p15.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (18412318..18452063)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (18510444..18550172)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (18433865..18473610)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:18415405-18416069 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:18416070-18416735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3191 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:18417470-18417971 Neighboring gene microRNA 3159 Neighboring gene lactate dehydrogenase A Neighboring gene lactate dehydrogenase A like 6A Neighboring gene ReSE screen-validated silencer GRCh37_chr11:18507685-18507894 Neighboring gene tumor susceptibility 101 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
    EBI GWAS Catalog
    Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120/41 (SFVenvBX08)-expressing microglia exhibit a 170% increase in lactate dehydrogenase (LDH) release PubMed
    Envelope transmembrane glycoprotein gp41 env A lentivirus lytic peptide 1 (LLP-1) corresponding to the carboxyl terminus of HIV-1 gp41 induces a significant lactate dehydrogenase (LDH, a marker of cell death) release from human neuronal and glial cell lines PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC111073

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in flagellated sperm motility IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lactate biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lactate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lactate metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in lactate oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pyruvate catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pyruvate metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus HDA PubMed 
    part_of oxidoreductase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    L-lactate dehydrogenase C chain
    Names
    LDH testis subunit
    LDH-C
    LDH-X
    cancer/testis antigen 32
    lactate dehydrogenase C4
    testis secretory sperm-binding protein Li 234P
    NP_002292.1
    NP_059144.1
    XP_047282890.1
    XP_054224722.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011816.2 RefSeqGene

      Range
      5002..44747
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002301.5NP_002292.1  L-lactate dehydrogenase C chain

      See identical proteins and their annotated locations for NP_002292.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC027544, AC084117
      Consensus CDS
      CCDS7840.1
      UniProtKB/Swiss-Prot
      D3DQY4, P07864, Q6GSG8, Q7Z7J4
      UniProtKB/TrEMBL
      A0A140VKA7, D6NKH9, G9BCY7, G9BCY8
      Related
      ENSP00000280704.3, ENST00000280704.8
      Conserved Domains (1) summary
      cd05293
      Location:18329
      LDH_1; A subgroup of L-lactate dehydrogenases
    2. NM_017448.5NP_059144.1  L-lactate dehydrogenase C chain

      See identical proteins and their annotated locations for NP_059144.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC027544, AC084117
      Consensus CDS
      CCDS7840.1
      UniProtKB/Swiss-Prot
      D3DQY4, P07864, Q6GSG8, Q7Z7J4
      UniProtKB/TrEMBL
      A0A140VKA7, D6NKH9, G9BCY7, G9BCY8
      Related
      ENSP00000437783.1, ENST00000541669.6
      Conserved Domains (1) summary
      cd05293
      Location:18329
      LDH_1; A subgroup of L-lactate dehydrogenases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      18412318..18452063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426934.1XP_047282890.1  L-lactate dehydrogenase C chain isoform X1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160006.1 Reference GRCh38.p14 PATCHES

      Range
      163770..166753
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      18510444..18550172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368747.1XP_054224722.1  L-lactate dehydrogenase C chain isoform X1